, Nair B.
, Kasturirangan V.
, Kariapper M.S.T.
, Nigavekar S.S.
, Toth K.
, Rustum Y.M.
, El-Jawahri A.
, Bizimungu R.
, Lesniak W.
, Balogh L.P.
, Roswell Park, US
We previously reported on the in vitro toxicity assessment of differently charged dendrimer-gold nanocomposites on normal cells (human endothelial cells) and prostate cancer cells (Khan et al., 2008). In this study we evaluate the in [...]
Polymer research and modern medicine are at a critical juncture. Many state of the art, small molecule therapeutics are difficult to deliver effectively because of poor solubility and rapid elimination by the reticuloendothelial system. In [...]
A promising approach to improve drug delivery is to modify a polymeric backbone structure by means of copolymerization. Such obtained macromolecular prodrugs (polymer–drug conjugates) may offer many advantages compared to other drug delivery systems: increased [...]
To provide an alternative route (non-swallowing) and compliance to patient (controlled release), nasal delivery of sulfonylureas is one of the best option among other routes for type II diabetes. Glibenclamide was selected as a model [...]
Nanoparticles based mucoadhesive system (diskettes), an alternative novel transmucosal (buccal) delivery of Fluoxetine hydrochloride (antidepressant drug, highly first pass effect) was developed. In this study, the drug was encapsulated into Sodium / Calcium salts of [...]
The intensive labor and high cost of developing new vehicles for the delivery of drugs in a controlled manner, highlights the need for a change in their discovery process. Predictive computational models can be used [...]
Paclitaxel (PTX) is an important anticancer agent. Its aqueous solubility is very low; hence the available formulation of PTX for clinical use consists of Cremophor EL, which has been associated with several hypersensitivity reactions. In [...]
Process design and development of oral, topical and parentral nanotechnology-based pharmaceuticals are presented. Factors affecting process output and scale-up choices for various dosage forms are discussed with emphasis on critical parameter control and optimization. For [...]
Depression is estimated to affect nearly 340 million people worldwide and 18 million people in the US at any given time [1-2], making it the third most costly and disabling illness in the US [3-8]. [...]
Avirulent Bacteria and parasites act as “tiny missile like carriers” capable to carry the magnetic nanoparticles (NMP) together with anticancer or radiosensitizer drugs at the tumor site. We compared the iron-oxide particles binding characteristics with [...]
Nitroimidazoles are radiosensitizers and hypoxia detecting chemosensitizers. Intially nitroimidazoles were single dose antibiotic drugs. Recently, nitroimidazole derivatives have emerged as multifunctional “drug-biomarker monitors” chemical compounds with importance in treatment of tumors, monitoring hypoxia and safer [...]
The objective of the research is to develop a new drug delivery system based on polyurethane microparticles for the treatment of tuberculosis by pulmonary administration to the lungs. The synthesis and characterization of polyurethane microcapsules [...]
Considerable advances have recently been achieved in the development of nano-scale particles for cancer diagnostics and therapies. ARmark Authentication Technologies, LLC has developed a new technology platform to produce stable multifunctional polymeric microcarrier delivery vehicles [...]
Long circulating pH-sensitive liposomes loaded with Paclitaxel were developed and characterized for the encapsulation efficiency, release characteristics and its action on B16F1 melanoma cells (low metastatic). Paclitaxel loaded pH-sensitive liposomes showed better release pattern and [...]
We have developed a dePEGylation approach based on the activity of the proteolytic enzymes that are associated with tumour cells. The elevated enzyme activity facilitates the extravasation of the cells by degrading the extracellular matrix [...]
The aim of this work was to develop Witepsol 85E solid lipid nanoparticles (SLN) containing insulin as biopharmaceutical, and to evaluate their potential for oral insulin administration. The new carrier was coated with chitosan in [...]
Current research on methods to target chemotherapy drugs in the human body includes the investigation of biocompatible magnetic nano-carrier systems, e.g. magnetic liquids such as ferrofluids. The aim of our work was to construct a [...]
Journal: TechConnect Briefs
Volume: 2, Nanotechnology 2009: Life Sciences, Medicine, Diagnostics, Bio Materials and Composites
Published: May 3, 2009
Industry sector: Medical & Biotech
Topics: Biomaterials, Materials for Drug & Gene Delivery