Cancer Nanotechnology – Page 20

Nanomedicine: Engineering of a Tri-Imageable Nanoparticle

Bumb A., Brechbiel M.W., Choyke P., Fugger L., Dobson P.J., National Cancer Instiute and University of Oxford, UK

We have created a potential targeted drug delivery platform with three imaging reporters by coupling the magnetic properties of USPIOs with near infrared fluorescence of Cy5.5 and gamma emissions of Indium-111 that is chelated to [...]

Nano Medicine

Sirna Nanomedicines for Cancer Gene Therapy

Kim S-H, Park T.G., Korea Advanced Institute of Science and Technology, KR

We developed a polyelectrolyte complex (PEC) micelle-based delivery system for treatment of prostate cancer. A PEGylated siRNA targeting human vascular endothelial growth factor (hVEGF) was synthesized. The hVEGF expression was almost completely inhibited in vitro [...]

Development of a specific micro/nanodevice validating the concept of molecular biopsy

Berger F., Bouamrani A., Cosnier M., Martin F., Caillat P., Benabid A.L., Inserm, FR

The nanomedicine concept implies early detection at the molecular level and molecular characterisation to implement a specific therapy. In this context, the development of micro/nanotool devoted for intra-tissular characterisation is indispensable. We first demonstrated that [...]

Characterization and in vivo efficacy of targeted nanoparticles for systemic siRNA delivery to tumors

Bartlett D.W., Davis M.E., California Institute of Technology, US

This abstract highlights the results from our latest work in the design and application of targeted nanoparticles for systemic siRNA delivery. Over the past several years, we have performed extensive physicochemical and biological characterization of [...]

Development of Nanoconjugate with Different Monoclonal Antibodies to Inhibit Molecular Targets Important for Tumor Angiogenesis

Fujita M., Khazenzon N.M., Lee B-S, Holler E., Black K.L., Ljubimova J.Y., Cedars-Sinai Medical Center, US

Tumor cell-specific drug targeting is the major goal of nanotechnology-based platforms. A nanoconjugate Polycefin was synthesized for targeted delivery of antisense oligonucleotides and antibodies into tumors. The delivery of antisense oligonucleotides to α4 and β1 [...]

Cancer Diagnostics, Imaging & Treatment

Functionalization of Magnetite (Fe3O4) Nanoparticles for Cancer Treatment

Herrera A.P., Rodríguez H.L., Torres-Lugo M., Rinaldi C., University of Puerto Rico-Mayagüez, US

We have studied the synthesis of magnetite (Fe3O4) nanoparticles functionalized with crosslinked dextran for magnetocytolysis application using human colon cancer cells (CaCo-2). Size of the magnetite nanoparticles was determined by SQUID, XRD, and TEM measurements, [...]

Laser Heating of Sulphuretted Carbon Nanoparticles Inhibits Tumor Growth

Kogan B.Ya., Yakubovskaya R.I., Pankratov A.A., Andreeva T.N., Kvacheva L.D., Titov A.A., Puchnova V.A., Feysulova R.A., Vorozhtsov G.N., Organic Intermediates & Dyes Institute, RU

Light-absorbing nanoparticles incorporated in a tissue can be heated by short-pulsed laser irradiation up to several thousand Kelvin degrees. Average tissue temperature may be kept normal if the concentration of these particles is low. Antitumor [...]

Application of Nanomagnetic Particles in Hyperthermia Cancer Treatment

Hayek S., Chen C-J., Haik Y., Hohite V., Florida State University, US

This research focuses on developing uniform particles with a Curie temperature that is similar to the therapeutic one for the purpose of cncer treatment. Such particles will self-regulate the temperature of the tumor during Magnetic [...]