Biomaterials – Page 108 – TechConnect Briefs

Elastic Properties of Aspergillus nidulans Studied with Atomic Force Microscopy

Zhao L., Schaefer D.M., Xu H., Modi S., LaCourse W.R., Marten M.R., Towson University, US

An atomic force microscopy (AFM) was used as a nanoindentor to measure cell wall mechanical properties of the model fungus Aspergillus nidulans in both hyphal and spore forms. Hyphae and spores were immobilized on polylysine-coated [...]

Bio-Detection and Chemical Fingerprinting using the Inductively Coupled Plasma Mass Spectrometer (ICP-MS) Technology

Adeyinka A., Kuzmanovic D., Schaefer D.M., Lev S., Towson University, US

In this project, we explored the bioaccumulation of a large variety of inorganic trace elements in Bacillus subtilis using an inductively coupled plasma mass spectrometer and compared it to other related and unrelated species. Bacillus [...]

Molecular Dynamics of Biomimetic Ionomers Studied by Dielectric Spectroscopy on the Nanometer Length Scale

Welch K., Nederberg F., Bowden T., Strømme M., Uppsala University, SE

New biomimetic materials are being developed which show great promise for biotechnological applications. An understanding of the dynamic molecular processes in these materials at the nanoscale level is of particular interest and we show that [...]

Studies on the Subcellular Trafficking of PAMAM Dendrimer

Lai P.S., Shieh M.J., Pai C.L., Wang C.Y., Lou P.J., National Taiwan University, TW

Polyamidoamine (PAMAM) dendrimers are a new class of highly branched spherical polymers and have emerged as a novel synthetic drug and gene carrier. However, the fate of the dendrimer-nucleotide complexes in a biological environment and [...]

High Speed Processing of Large Amount of Bio-Nano Imaging Data for Cancer Research

Wang G., Wang M., Wang G., Wang M., Georgia Institute of Technology and Emory University, US

Bionanotechnologies such as quantum dots (QDs) or molecular beacons have generated huge amount of nanoimaging data to study in vitro and in vivo cell behavior for disease early diagnosis and therapeutic drug target. These images [...]

Mesoporous Silica for Desorption-Ionization Mass Spectrometry

Dattelbaum A., Iyer S., Los Alamos National Laboratory, US

Here we demonstrate the use of mesoporous silica thin films for matrix free laser desorption/ionization mass spectrometry (MS). In spite of the growing acceptance of matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry for biomolecular analysis, [...]

Bio Nano Analysis and Characterization

Synthesis and Properties of Magnetic Nanoparticles with Potential Applications in Cancer Diagnostic

Neamtu J., Jitaru I., Malaeru T., Georgescu G., Kappel W., Alecu V.-V., National Institute for Research, RO

The size, shape and composition of magnetic nanoparticles are very attractive for diagnostic tools of cancer tumors and targeting treatment in HIV infection. The goal of this paper is the preparation from colloidal solutions of [...]

Water-Soluble, Carboxyl-Modified Silicon Nanoparticles

Lee S., Cho W-J, Korea Institute of Science and Technology, KR

Since silicon has both the well-known chemistry and the industrial benefits of non-toxic and low cost, an interest in Si nanoparticles has rapidly increased. We will discuss a practical surface modification of Si nanoparticles prepared [...]

Formation of Polymer Nano-particles in Supercritical Fluid Jets

Gokhale A.A., Khusid B., Dave R.N., Pfeffer R., New Jersey Institute of Technology, US

The supercritical antisolvent process is an emerging technology for the production of micro- and nanometer-sized particles for a wide variety of bio-medical pharmaceutical applications. In this method, an organic liquid solution of the compound of [...]