Medical & Biotech – Page 7 – TechConnect Briefs

Quantitative Electrolateral Flow Immunosensor (ELLI): Dengue Triage and Stroke Prognosis Case Studies

Sinawang P.D., Fajs L., Marks R.S., Ben-Gurion University of the Negev, IL

The development of a rapid, affordable, and sensitive diagnostic kit for point-of-care is important in most healthcare settings; however, only a few exhibit the needed quantitative capability. Our technology, ELLI, is a patented diagnostic device [...]

Nanobiomimetic Superlattice Superconductive/Memristive Organometallic Devices at Room Temperature Serve as Chronoamperometric Sensors for sub fg/mL Collagen-1 Detection in Human Serum

Chen E.T., Thornton J.T., Kissinger P.T., Duh S-H, Advanced Biomimetic Sensors, Inc., US

Superconductive/Memristive devices have potential applications in supercomputing and in health industry was proposed in literature. Clinically detection range at low concentration for collagen-1 is difficult to accomplish due to the denaturing of protein Matrix Matelloprotinase-2 [...]

Multiplex Express In Vitro Diagnostics based on Magnetic Nanoparticles

Nikitin M.P., Nikitin P.I., Guteneva N.V., Bragina V.A., Znoyko S.L., Orlov A.V., Gorshkov B.G., Nikitin M.P., Nikitin P.I., General Physics Institute, Russian Academy of Sciences, RU

Magnetic nanoparticles (MP) have provided many breakthrough solutions for life science. The immense potential of MP as labels in advanced immunoassays stems from the fact that they, unlike optical labels, can be easily detected inside [...]

Diagnostics & Bioimaging

Hybrid Programmable Peptide Crosslinkers as Enzyme-Regulated Drug Delivery Vehicles

Rouge J.L., University of Connecticut, US

Biology has evolved the quintessential nucleic acid delivery vehicle, the virus, using proteins built from self-assembled peptide subunits. These viral protein coats are then degraded by specific enzymes, depending on their location, releasing their contents [...]

Zwitterionic Polymer Surfactants for Drug Delivery

Cao Z., Wayne State University, US

Zwitterionic polymers have found a wide range of applications based on excellent non-fouling properties. It has been demonstrated that their use as surface coatings can effectively resist binding from proteins, cells, and full blood. Nanoparticles [...]

Functional Polylactide-based Systems for Delivery of Cancer Therapeutics

Cheng C., Sun H., Yu Y., Chen C-K, Cheng C., Zou J., University at Buffalo, the State University of New York, US

As an important class of biodegradable polymers, polylactides (PLAs) have been approved by FDA for clinical applications. However, conventional PLAs are lack of functionalities, and this significantly limits their applications. Therefore, in recent years we [...]

Nanodelivery of Chinese traditional medicine extract of Gingko Biloba (EGb-761) induces superior neuroprotection following traumatic brain injury in heat stroke

Sharma A., Sharma H.S., Muresanu D.F., Lafuente J.V., Zhang Z-q, Li C., Patnaik R., Tian Z.R., Ozikzilcik A., Sharma A., Sharma H.S., Uppsala University, Uppsala, SE

Military personnel are often exposed to high summer heat resulting in heat stroke (HS) and related illnesses. HS often results in serious mental and physical consequences due to breakdown of the blood-brain barrier (BBB) to [...]

TiO2 nanowired delivery of cerebrolysin induces superior neuroprotection following exacerbation of blast brain injury pathophysiology in diabetes

Muresanu D.F., Sharma A., Sharma H.S., Lafuente J.V., Nozari A., Patnaik R., Nozari A., Ozkizilcik A., Tian Z.R., Mössler H., Sharma A., Sharma H.S., University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca, Romania, RO

Blast brain injury (bBI), a combination of pressure, rotation, penetration of sharp objects and chemical exposure is prevalent in military personnel during combat operations causing laceration, perforation and tissue loss in the brain. Since combat [...]

Intraspinal administration of TiO2 nanowired cerebrolysin with mesenchymal stem cells has superior neuroprotective effects on cord pathology and functional outcome following a focal spinal cord trauma

Feng L., Sharma A., Sharma H.S., Niu F., Huang H., Lafuenta J.V., Muresanu D.F., Ozkizilcik A., Tian Z.R., Sharma A., Sharma H.S., Bethune International Peace Hospital, CN

Military personnel are often victims of spinal cord injury (SCI) for which there is no suitable treatment available. Thus, exploring new therapeutic avenues using select combination of novel neuroprotective agents is the need of the [...]