Medical & Biotech – Page 51 – TechConnect Briefs

Encapsulation and Characterization of BSA in PLA-PEG Nanoparticles as a Model for Chlamydia trachomatis rMOMP-278 Protein Nanovaccine Delivery System

Taha M., Singh S.R., Moore C., Agee R., Dennis V.A., Alabama State University, US

Chlamydia trachomatis is a major human health pathogen because it is the most reported sexually transmitted disease. There is no effective mucosal vaccine against Chlamydia. One of the major problems of the C.trachomatis vaccine development [...]

In vitro anticancer activity of poly(3-hydroxybutyrate) nanoparticles loaded with antitumor drug Paclitaxel

Yakovlev S.G., Bonartsev A.P., Bonartseva G.A., Bagrov D.V., Efremov Yu.M., Boskhomdzhiev A.P., Filatova E.V., Ivanov P.V., Makhina T.K., Bonartseva G.A., A.N.Bach’s Institute of Biochemistry Russian Academy of Sciences, RU

We have produced nanoparticles loaded with antitumor drug paclitaxel. Operated nanospheres were prepared on the base of a biodegradable and biocompatible polymer of bacterial origin, poly(3-hydroxybutyrate) (PHB). PHB nanoparticles with paclitaxel (230±55 nm in diameter) [...]

Orally Delivered Polymeric nanoparticles of Lopinavir: Development and Statistical optimization, in vitro and ex vivo studies

Joshi G., Sawant K.K., M S University of Baroda, IN

Nanoparticles (NPs) have been extensively studied for oral drug delivery. NPs are taken up intact by M cells of peyer’s patches of gut associated lymphoid tissue (GALT) followed by its systemic circulation thereby preventing first [...]

Supramolecular assemblies of cisplatin and polyelectrolytes: preparation, characterization and activity against cancer cells

Vieira D.B., Kim V., Petri D.F.S., Menck C.F.M., Carmona-Ribeiro A.M., Universidade de Sao Paulo, BR

Nanoformulation of cisplatin (Cis) is important to circumvent its high toxicity against normal cells. In this work, Cis cationic nanoparticles were prepared by the self-assembly of drug and oppositely charged polyelectrolytes (carboxymethylcellulose, CMC; chitosan, CH; [...]

Self Assembled Nanostructures of Triblock Co-polymer and Plasmid DNA for Gene Delivery

Daima H.K., Shankar P.R. Selvakannan S., Bhargava S.K., Bansal V., RMIT University, AU

In present work, we have used tri-block copolymer (PEO-PPO-PEO) as a non-viral vector to deliver plasmid DNA (pDNA). Green fluorescence protein (GFP) plasmid DNA was used as a model plasmid DNA. Addition of pDNA to [...]

Nanostructured cellulose materials: adsorption of antibiotics onto cellulose fibers functionalized with glycidylmethacrylate for the manufacturing of antibacterial fabrics

Vismara E., Torri G., Valerio A., Graziani G., Montanelli A., Melone L., Politecnico di Milano, IT

Abstract: In this work we report how cotton fibers can be easily functionalized with glycidylmethacrylate (GMA) by means of the Fenton’s reaction and used for the manufacturing of biomedical textiles having significant capability to adsorb [...]

Designing Responsive Materials with Chemically Amplified Sensitivity to NIR light

Fomina N., McFearin C., Sermsakdi M., Morachis J., Almutairi A., University of California at San Diego, US

We employ near infrared (NIR) light as an external trigger for controlled material degradation and targeted release of a payload. NIR light can penetrate through tissues to an appreciable depth without scattering or damaging it. [...]

Electrospun Nanofibrous Scaffold for Controll Drug Delivery

Leung V., Hartwell R., Faure E., Yang H., Ghahary A., Ko F., University of British Columbia, CA

This study aims to design methods for controlling drug release from polymer nanofibres, and use these methods as a guide for designing nanofibre wound dressings with customizable release profile for a range of drugs. The [...]

Surfactant Effect on Intercellular Transport of DNA, Proteins, and Electrolytes

Assan D., Gao X., Lai J.C.K., Leung S.W., Idaho State U, US

Surfactants play a key role on bodily functions at molecular level, such as cell signaling and signal transmission. Their importance in cell survival is well recognized, but the surfactant effect on intermolecular/interfacial mass transport is [...]

Development of PHEMA-Chitosan nanospheres and encapsulation of RSV-F DNA vaccine

Eroglu E., Waffo A.B., Dennis V.A., Singh S.R., Alabama State University, US

Respiratory Syncytial Virus (RSV) causes serious lower respiratory tract diseases among infants. Unfortunately, no effective vaccine to prevent RSV infection has been developed. RSV fusion gene (RSV-F) is conserved among various strains of RSV. Therefore, [...]