Medical & Biotech – Page 52 – TechConnect Briefs

Sequential Surface Functionalization by Polyoxometalates and Lysine Renders Non-toxic Gold Nanoparticles Strong Antibacterial Agents

Daima H.K., Selvakannan P.R., Bhargava S.K., Bansal V., RMIT University, AU

Gold nanoparticles (AuNPs)are considered as biocompatible and important component for biomedical applications. In current study, AuNPs were synthesised using tyrosine amino acid mediated reduction of gold ions. These nanoparticles were functionalised with two polyoxometalates (POMs) [...]

Controlled- Release Antibiotic Nanoparticles for Cranial Transplantation and Bone Grafting

Adusumilli A.N., Dammalapati S., Fu P.K.-L., Governors State University, US

The objective of this research is to develop a unique nanoparticulate system that is capable of delivering antibiotics in a locally applied and extended-release manner for patients receiving cranial replacement implants and bone grafting. This [...]

Surface Functionalized Multicomponent Envelope Type Nanosystems for Improved Gene Delivery

Pozzi D., Orlando V., Augusti Tocco G., Biagioni S., Cardarelli F., Bifone A., Caraccioloa G., Sapienza University of Rome, IT

Recently, a new programmed packaging strategy in which various “soft devices” that control intracellular trafficking are incorporated into single nanoparticles has been proposed. Here we apply such a novel concept to develop multicomponent envelope-type nanosystems [...]

Dual Modal Gene Expression and Silencing Using Viral/Nonviral Chimeric Nanoparticles for Synergistic Gene Therapy

Cho S.K., Luu T., Wong S., Kwon Y.J., UC Irvine, US

Efficient, safe, and versatile gene delivery carriers that combine the viral vectors’ high gene delivery efficiency and the nonviral vectors’ high level of flexibility for structural and functional modifications were prepared. Adeno-associated virus (AAV) was [...]

A Novel Single Step Method of Synthesizing Large Unilamellar Liposomes for Biomedical Applications

Phapal S.M., Sunthar P., Indian Institute of Technology - Bombay, IN

We have investigated various coacervation techniques for liposome synthesis. The aim is to study various local mixing conditions and their effect on the size of liposomes formed. To control the extent of mixing, four different [...]

Drug Delivery with Light-Activated Gold-Coated Liposomes

Orsinger G.V., Leung S.J., Knights S.S., Williams J.D., Romanowski M., University of Arizona, US

With the ultimate goal of delivering therapeutic compounds selectively to cancerous or diseased tissues and cells, we have presented liposome-based plasmon resonant nanocapsules. The described biocompatible composite delivery vehicle enables encapsulation and selective release of [...]

Triple protection delivery system for retinaldehyde: Preparation, skin penetration and controlled release at the hair follicles

Supmuang P., Wanichwecharungruang S., Chulalongkorn University, TH

Vitamin A and its derivatives including retinaldehyde possess serious instability problem. To continuously supply skin with un-degraded retinaldehyde, nanoparticles which could penetrate into skin via hair follicles and then slowly release this vitamin A derivative [...]

Electrically-Controlled Drug Release System to Assist Wound Healing

Zhu S., Mbugua J., Chase M., Maskrod J., Jung J.H., Nicholson III T., Fabrizio E., Mercado R., Crosslink, US

The localized, controlled delivery of therapeutic agents is an attractive prospect for drugs with detrimental systemic effects at large dosages. An electronically-controlled drug delivery system (DDS) for the controlled release of negatively charged model compounds [...]

Materials for Drug & Gene Delivery

Novel Organofunctional Silane Coatings on Silica-Coated Ti

Matinlinna J.P., Tsoi J.K.H., The University of Hong Kong, HK

This in vitro study characterizes a developed novel silane system method to produce coatings on Ti. Hydrophobic coatings are needed in prosthetic dentistry to promote durable adhesion between luting resin cements and coated Ti surfaces. [...]