Papers – Page 237 – TechConnect Briefs

Fabrication of stable bio-compatible mesoporous silica and core-shell silica-magnetite nanoparticles for potential application in drug delivery

Sharifabad M.E., Mercer T., Sen T., University of Central Lancashire, UK

Superparamagnetic iron oxide nanoparticles (SPIONs) have become increasingly attractive materials in the field of Nano / Nano-biotechnology due to their potential applications in heteogeneious catalysis [1, 2], nanomedicine such as drug delivery [3, 4], cell [...]

Development of Drug Delivery System Using Bio based Calcium carbonate Nanoparticles

Render D., Rangari V., Samuel T., Ramapuram J., Pawar K., Jeelani S., Tuskegee University, US

The CaCO3 nanoparticles were derived from egg shells using sonochemical and mechanochemical methods. The glycerol and acetic acid were used as solvents in this process to avoid other toxic solvents. These nanoparticles were loaded with [...]

Non-ionic Dendronized Multiamphiphilic Polymers as Nanocarriers for Biomedical Applications

Gupta S., Schade B., Kumar S., Böttcher C., Haag R., Sharma S.K., University of Delhi, IN

Several supramolecular architectures on the nanoscale have become important candidates for potential applications in nanomedicine, particularly for drug, dye, and gene delivery. Out of various conceptual extensions for the development of such molecular objects, our [...]

Programming and switching the pharmacokinetics of nanoscale delivery vehicles in vivo

Chien M.-P., Gianneschi N.C., University of California San Diego, US

It has been shown that the morphology of nanomaterials greatly impacts the pharmacokinetic profile of the material, with larger micronscale fibril-like objects having longer circulation times while smaller nanomaterials show a greater rate of internalization [...]

Nanosystem for targeting Treg in vivo

Bottini M., Bottini N., Sacchetti C., Rapini N., Rosato N., Magrini A., Bottini M., Bottini N., Sanford Burnham Medical Research Institute, US

Due to their ability to suppress the activity of autoreactive cells, “natural” CD4+ CD25high FoxP3+ T cells (Treg) are important drug targets for autoimmune diseases and malignancies. Immunological studies are revealing a growing subset of [...]

Lipid nanoparticles for enhancing immune responses to protein antigens

Courant T., Reynaud H.L., Hoang A., Villiers C., Mittler F., Texier I., Marche P.N., Navarro F.P., CEA/LETI/MINATEC, FR

In the near future, novel vaccines will be needed, particularly nanoparticles-based vaccine formulations for figthing problematic infectious diseases like tuberculosis, AIDS/ HIV or malaria and also cancers. Here, we described the development of versatile chemical [...]

Thermosensitive Vaginal Gel Containing PLGA-NTRI Conjugate Nanoparticles for HIV Prophylaxis

Rajca A., Li Q., Date A., Destache C., Creighton University School of Pharmacy & Health Professions, US

A critical component to the prevention of the sexual transmission of HIV is adherence to the prevention modality. We have conjugated nucleoside-reverse transcriptase inhibitors (NRTIs) to a biocompatible polymer, PLGA using an amide bond. We [...]

Reduction-sensitive hyaluronic acid nanoparticles for targeted intracellular deliery of doxorubicin

Saravanakumar G., Shin J.M., Um W., Park J.H., Sungkyunkwan University, KR

Disulfide-containing HA dodecyl conjugates (HA-SS-DDTs) were synthesized using the facile thiol-exchange reaction as the carrier for intracellular delivery of doxorubicin (DOX). Owing to its amphiphilicity, HA-SS-DDT could form self-assembled nanoparticles in an aqueous condition. The [...]

Approaches to surface-functionalised materials for biomedical applications

Pitt D.W., Treharne A., Grossel M.C., University of Southampton, UK

There are many types of retinal disease which vary widely, with some being easier to treat than others. One such example is Age-Related Macular Degeneration (AMD) which is the largest cause of blindness for those [...]

A Molecular Modeling Approach towards Engineering of Polymer Nanogels for Controlled Drug Delivery

Dutta R.C., Rai B., Tata Research Development and Design Centre, IN

Traditionally, a drug is administered initially at a higher dosage so as to repeat the next dose after several hours or days. This, besides being un-economical, results in side effects. Recently, there has been an [...]