MRI – TechConnect Briefs

Novel Nanoparticle Contrast Agents for Magnetic Resonance Imaging

Van Keuren E., Stoll S., Dahanayake V., Lyons T., Glaser P., Albanese C., Rodriguez O., Fricke S., Georgetown University, US

Magnetic resonance imaging (MRI) is an important diagnostic tool in both clinical and research environments. In order to improve sensitivity, contrast agents (CAs) are often administered prior to or during imaging sessions. We have been [...]

Machine Learning for Automated Hepatic Fat Quantification

Sagreiya H., Akhbardeh A., Durot I., Rubin D.L., University of Pennsylvania, US

Nonalcoholic fatty liver disease is a global pandemic. This study investigated whether ultrasound point shear wave elastography measurements could predict hepatic fat quantification using a machine larning (ML) algorithm trained with fat quantification on MRI. [...]

Nephrotoxicity of Dextran Functionalized Graphene Nanoparticles and Their Potential as Magnetic Imaging Contrast Agents for Renal Abnormalities

Lee S., Kanakia S., Toussaint J., Kukarni P., Chowdhury S.M., Khan S., Shroyer K., Moore W., Sitharaman B., Stony Brook University, US

Contrast-enhanced magnetic resonance angiography (MRA) employs the use of blood pool contrast agents (CA) such as gadolinium (Gd3+) complexes that allow for delayed phase arterial and venous imaging and improve the sensitivity in detecting small [...]

Single Crystalline Micrometric Iron Oxide Particles with Superparamagnetic Behaviour for MRI Applications

Kiss M.L., Chirita M., Beljung C.A., Polanek R., Savii C., Ieta A., Ionut Mihaila Chirita A., State University of New York at Oswego, US

A major drawback of using metal oxide nanoparticles as contrast agent in MRI is related to their low saturation magnetization mainly due to their particle size. The current works seeks to solve this problem by [...]

Application Magnetite of Nanoparticles (ICNB Preparation) as Magnetically-Resonant Contrasting Means During Visualization of Tumours

Belousov A.N., Laboratory of Applied Nanotechnology Belousova A.N., UA

In investigation on animals (Vistar rats) was proof that magnetite of nanoparticles (ICNB) are contrast means for malignant tumour visualization. Was been shown that magnetite of nanoparticles have contrast effect when performing magnetic resonance imaging [...]

Novel Photo-thermal Controlled Drug-releasing Vectors for Cancer Detection and Treatment

Tsai M-H, Ling D., Shieh M.J., National Taiwan University, TW

Cancer is always the leading cause of deaths in worldwide. The aim of this research is to develop a new generation of chemotherapeutic drugs with both photothermal activated drug release and MRI diagnostic function. Carbon [...]

Imaging the Distribution of High Colloidal Stability Mesoporous Silica Nanoparticles (MSNs) with PET and MRI

Laprise-Pelletier M., Bridot J.-L., Guillet-Nicolas R., Lagueux J., Gossuin Y., Laurent S., Vander Elst L., Kleitz F., Fortin M.-A., Université Laval, CA

Biocompatible and high porosity mesoporous silica nanoparticles (MSNs) represent a significant advance in drug delivery applications, currently entering clinical validation. It will be necessary to track these drug vectors over time with medical imaging techniques. [...]

Development and Application of a Rod and Sphere-Shaped Viral Nanoparticle MRI Contrast Agent for Atherosclerosis Diagnosis

Bruckman M.A., Steinmetz N.F., Case Western Reserve University, US

The use of nanoparticles to deliver magnetic resonance (MR) contrast agents to enhance MR sensitivity has shown great potential in identifying and diagnosing diseases such as cancer and cardiovascular disease. A common challenge is the [...]

Application Magnetite of Nanoparticles (ICNB Preparation) as Magnetically-Resonant Contrasting Means During Visualization of Tumours

Belousov A.N., Laboratory of Applied Nanotechnology Belousova A.N., UA

In investigation on animals (Vistar rats) was proof that magnetite of nanoparticles (ICNB) are contrast means for malignant tumour visualization. Was been shown that magnetite of nanoparticles have contrast effect when performing magnetic resonance imaging [...]

PLGA-PEG multifunctional nanoparticles for simultaneous drug delivery and imaging by MRI and fluorescence microscopy

Fornara A., Chiavarino A., Qin J., Toprak M.S., Muhammed M., YKI, Institute for surface chemistry, SE

In recent years, a lot of effort has been put to develop smart nanocarriers for drug delivery to increase the efficacy of certain therapeutic drugs. Still the main challenge is to integrate the therapeutic function, [...]