liposome – TechConnect Briefs

Modeling of polypeptide- and polymer-conjugated nanoparticles for drug delivery application

Lee H.K., Dankook University, KR

Nanoparticles such as liposomes, dendrimers, and carbon nanotubes have many potential biomedical applications as antitumor therapeutics and drug delivery. These applications require the interaction of those with cell membranes, thus interactions of nanoparticles, polymers, and [...]

Novel Nano-biomaterials for Inhibition of Respiratory Syncytial Virus

Joshi S., Kirby D., Perrie Y., Singh S.R., Alabama State University, US

The liposomes were prepared using the conventional thin film hydration method with and without peptide RF-482. The loading of RF-482 was determined using BCA assay and the RSV inhibition was studied using immune-fluorescence imaging, plaque [...]

Rapid High Resolution Multi-Parameter Characterization of Liposome-Protein Complexes by Nanoparticle Tracking Analysis

Esposito E., Griffiths D., Ragheb R., Malvern Instruments, US

Aggregation of biological and synthetic materials is a source of tremendous concern, posing problems at various stages of discovery and formulation processes. The ability to identify and characterize aggregates is of broad utility, and experiments [...]

Applying Plasmon Resonant Coating to Commercial Liposomal Delivery Systems

Knights-Mitchell S.S., University of Arizona, US

Multiple drug-encapsulated liposomes have been successfully marketed as pharmaceuticals within the past two decades. Some of these liposomal drugs have been shown to selectively localize within tumors. However, one limitation is the inability to control [...]

Surface Structure of the drug delivery liposome

Magarkar A., University of Helsinki, FI

The criteria for effectiveness of drug delivery liposomes (DDLs) are structural stability, site specific targeting, and lifetime in the bloodstream. Often to increase the lifetime in bloodstream DDL is coated with poly ethylene glycol (PEG). [...]

Optical Trapping of Gold-Coated Liposomes

Leung S.J., Romanowski M., University of Arizona, US

We recently introduced a nanocomposite material, plasmon resonant gold-coated liposomes, to address unmet needs in area of controlled delivery. Plasmon resonant nanocapsules are created via the deposition of gold onto the surface of 100 nm [...]

A proof of concept: a model of targeted stealth nanoparticles that are stable and biocompatible for RNA interference in vivo to macrophages

Miller A.D., Prata C.H., Yusuf M.S., Imperial College Gene Therapies Centre, UK

Bringing together advances generated through the developing fields of bionanotechnology and gene therapy, and demonstrated through the ABCD model, we propose a biocompatible, stable, specific stealth lipoplex targeting macrophages, as proof of concept, which is [...]

Magnetoliposomes: Stability of Magnetic Nanoparticles in Suspension for drug delivery

Elhissi A., Mercer T., Sen T., Sheppard S.J., University of Central Lancashire, UK

A simple and rapid one pot method of synthesis of magneto-liposome has been reported. The nanoparticles exhibited exceptional stability in suspension. Magnetoliposomes were efficient for DNA binding/elution and drug loading.

Structural Elucidation of Doxorubicin-Loaded Liposomes by Atomic Force Microscopy in air and water

Al-Jamal W.T., Kostarelos K., Stuartb M., Tian B.W., The School of Pharmacy, University of London, UK

Doxil is a clinically used, FDA-approved liposomal product against cancer. Structural elucidation of liposomal doxorubicin by cryogenic-transmission electron microscopy (cryo-EM) showed that doxorubicin (Dox)form crystal-like structures inside liposomes. Since 1992, cryo-EM has been the only [...]

Temperature Sensitive Liposomes for Local Drug delivery Using Focused Ultrasound

Contag C., Guccione S., Larabi M., Mackanos M., Shinde R., Stanford University, US

Local delivery of therapeutic drugs will increase drug concentration at the site of treatment for maximum efficacy, and reduce systemic drug exposure. The encouraging results obtain in first phase of the clinical study of doxorubicin [...]