liposome – Page 2 – TechConnect Briefs

Organisation of peptide ligands on the surface of gene vectors

Wang M., Miller A.D., Thanou M., Imperial College London, UK

Through the considerate organisation of surface ligands, we have developed a lipid-based vector for the targeted delivery to cancer cells. Our ligand is a short peptide with high affinity for the Urokinase Plasminogen Activator receptor [...]

Spontaneously Forming Unilamellar Nano-Sized Vesicles – Polydispersity, Size, Shape and Stability

Nieh M-P, Raghunathan V.A., Huang C-Y, Pencer J., Harroun T., Katsaras J., National Research Council at Canada, CA

Unilamellar vesicles (ULV) made up entirely of biologically relevant materials can serve as carriers for drug delivery or gene therapy. Compared to extrusion and sonication methods, traditionally used for producing ULV, spontaneously forming ULV offer [...]

In Vivo Tracking of Liposomes Using CT and MR Imaging

Zheng J., Liu J., Jaffray D.A., Allen C., University of Toronto, CA

Currently, there are limited methods available for longitudinal and non-invasive in vivo assessment of the transport kinetics of carrier-based therapeutics, such as those relying on liposomes. A viable strategy to non-invasively track the carrier in [...]

Temperature-Triggered Nanotechnology for Chemotherapy: Rapid Release From Lysolipid Temperature-Sensitive Liposomes

Mills J.K., Needham D., Duke University; presently Sterne, Kessler, Goldstein & Fox, P.L.L.C., US

Despite advances in drug retention and evasion of the body’s defenses, the therapeutic efficacy of many liposomes has been limited by low drug bioavailability within the tumor. Developed in this laboratory in 1996, lysolipid temperature [...]

Liposome Encapsulation of Fluorescent Nanoparticles: Quantum Dots and Silica Nanoparticles

Chen C-S, Yao J., Durst R.A., Cornell University, US

Quantum dots (QDs) and silica nanoparticles (SNs) are new classes of fluorescent probes that overcome the limitations encountered by organic fluorophores in bioassay and biological imaging applications. We encapsulated QDs and SNs into liposomes by [...]

Structural Characterization of Novel Micro- And Nano-Scale Non-Viral DNA Delivery Systems for Cutaneous Gene Therapy

Foldvari M., Badea I., Wettig S., Verrall R., Bagonluri M., University of Saskatchewan, CA

Our main goal is to develop micro/nano-scale self-assembling delivery vehicles for cutaneous gene therapy. The objective of this study was to characterize the structural and physicochemical properties of novel dicationic lipid-based DNA complexes by atomic [...]