gold nanoparticle – TechConnect Briefs

Ultra Uniform Colloidal Particles as Nanoscale Reference Materials

Garcia, D.A., Oldenburg, S.J., Saunders, A.E., nanoComposix, Inc., US

The ability to understand and predict the properties of nanomaterials relies on an accurate measurement of their size, shape, number density, and other physical properties. One challenge associated with many measurement techniques is the lack [...]

Zn(II)-Mediated Gold Nanosensors for Protein Phosphatase Assay

Kim, G.B., Kim, Y.P., Lee, J-O, Hanyang University, KR

Since gold nanoparticle (AuNP)-based colorimetric assays have been preferred for enzyme activity assay,[1] a few of attempts have been designed for the simple and rapid detection of PP activity. However, they still have drawbacks including [...]

Amplified On-Chip Fluorescent and Colorimetric Detection of DNA and RNA Hybridization by Surface-Initiated Enzymatic Polymerization

Chilkoti, A., Hucknall, A., Tjong, V., Yu, H., Duke University, US

We present a new on-chip, isothermal signal amplification technique for direct detection of unmodified DNA and RNA on microarrays using terminal deoxynucleotidyl transferase (TdT), a template-independent DNA polymerase that catalyzes the sequential addition of deoxynucleotides [...]

Targeted Cancer Therapy by Immunoconjugated Gold-Gold Sulfide Nanoparticles Using Protein-G as a Cofactor

Gobin, A.M., Patel, D., Sun, X.H., Zhang, G.D., University of Louisville, US

Gold-gold sulfide nanoparticle (GGS-NP) with controllable near infrared (nIR) absorption was synthesized from a simple reaction of chloroauric acid and sodium thiosulfate. Through PEGylated recombinant Protein-G (ProG), ProG-conjugated GGS-NPs for antibody capture by Fc domain [...]

Plasmonic nanoparticles ordered in self-assembled materials

Aradian, A., Merchiers, O., Nallet, F., Ponsinet, V., Sivasankaran, P.C., Tallet, C., Vieaud, J., Centre de Recherche Paul Pascal, FR

Bottom-up approaches, and among them nanochemistry and self-assembly, have recently appeared as promising tools for the fabrication of plasmonic nanostructured materials. We study nanocomposites of polymers and gold nanoparticles presenting plasmonic resonance at a visible [...]

The Intracellular Co- localizations of Different Size of Gold Nanoparticles

Boyoglu, C., Boyoglu-Barnum, S., He, Q., Miller, M.E., Singh, S.R., Soni, S., Willing, G., Alabama State University, US

Gold nanoparticles (GNPs) are widely used in biological and clinical applications due to their favorable optical and chemical properties. The scientific understanding of the intracellular uptake of GNP is required for biomedical applications, such as [...]

Folate-Conjugated Gold Nanoparticles for Cancer Nanotechnology Applications

Brandenburg, K.S., Mansoori, G.A., Shakeri-Zadeh, A., University of Illinois at Chicago, US

A need exists to target cancer treatments specifically to the tumor site, without damaging healthy tissue. This need can be achieved through the proper application of nanotechnology, namely gold nanoparticles conjugated to Folate. Folate is [...]

Plasmonic Nanobubbles as Tunable Theranostic Agents

Carson, D.D., Constantinou, P., Danysh D.S. Wagner, B., Drezek, R.A., Farach-Carson, M.C., Hafner, J.H., Lapotko, D.O., Lukianova-Hleb, E., Rice University, US

Plasmonic nanobubbles (PNB) were developed to support a cell level theranostics as the multi-functional, tunable and selective cellular probes. PNB is a transient and tunable vapor nanobubble that is generated on demand around overheated plasmonic [...]

Layer-by-Layer Deposition of Cationic Polymers on Gold Nanoparticle for Non-viral Gene Delivery System

Saengkrit, N., National Nanotechnology Center (NANOTEC), TH

In this study, gold nanoparticles displayed spherical shapes with an average size of 12 nm were synthesized. The nano-carriers for gene delivery were subsequently developed based on DNA adsorption on the gold/cationic polymer-scaffold. The multilayer [...]

Highly stable and orientationally coupled gold nanoparticle antibody conjugates for sensitivity improvement in LFIA

Ijeh, M., Vossmeyer, T., Weller, H., University of Hamburg, DE

LFIAs are used in the investigation of a variety of bio-molecular binding interactions and they remain the primary means for point of care and fast detection of analytes including pathogens and toxins. In a novel [...]