cytotoxicity – TechConnect Briefs

Cytotoxic Effects of Short Multi-Wall Carbon Nanotubes on Pancreatic Cancer Cells

Lai J.C.K., Desai V., Zhang Y., Bhushan A., Leung S., Idaho State University College of Pharmacy, US

Although carbon nanotubes (CNTs) are increasingly exploited in diverse industrial and biomedical applications, their health hazard to humans is poorly understood. We have developed many cell models in vitro to systematically study the putative cytotoxicity [...]

The characterization and reductive degradation behavior study of bioreducible crosslinked polypropylenimine dendrimers for gene delivery systems

Lee G.J., Ryu K., Kim T.I., Seoul National University, KR

Polypropylenimine (PPI) dendrimers and their derivatives have been used for gene delivery because of their properties such as cationic charge, equivalent surface functionalities, and internal cavities [1–4]. However, high generation PPIs made high cytotoxicity induced [...]

One and two dimensional inorganic nanoparticles’ interactions with fibroblasts and stem cells

Rashkow J.T., Talukdar Y., Lalwani G., Sitharaman B., Stony Brook University, US

We report the effects of one and two dimensional transition metal dichalcogenide nanoparticles, tungsten disulfide nanotubes (WSNTs) and molybdenum disulfide nanoplatelets (MSNPs), on fibroblastic cell (mouse fibroblasts (NIH-3T3) and human adipose derived stem cell (MSC)) [...]

Zinc Oxide Nanoparticles Induced Apoptosis and Necrosis in Human Neuroblastoma and Astrocytoma Cells

Lai J.C.K., Lai M.B., Balaraju A.K., Neti A., Lai J.C.K., Lai M.B., Tadinada S.M., Idikuda V.K., Singh M.R.M., Mukka K., Pfau J., Bhushan A., Leung S.W., Idaho State University College of Pharmacy, US

Because of their escalating uses in industrial and biomedical applications, humans are increasing exposed to nanoparticles in occupational and other environmental settings. However, the environmental safety and health impact of such particles have not been [...]

Cellular uptake and cytotoxic effect of broccoli phytochemical based gold nanoparticles (B-AuNPs): Enhanced cancer therapeutic efficacy

Khoobchandani M., Katti K., Katti K.V., Zambre A., Katti K., Katti K.V., University of Missouri, US

The interaction phytochemicals from Broccoli with gold salt results in dual reduction and surface capping to produce well-defined stable and biocompatible gold nanoparticles. The core sizes of B-AuNPs are in the range of 10–20 nm [...]

Cytotoxicity of Magnesium Oxide Nanoparticles in Schwann Cells

Idikuda V.K., Jaiswal A.R., Wong Y.Y.W., Bhushan A., Leung S.W., Lai J.C.K., Idaho State University, US

Diverse applications of metal oxide nanoparticles in various industries have been accelerating in the last decade. Magnesium oxide (MgO) nanoparticles have been employed in ceramics, and as adhesive and additive in chemical raw materials, leading [...]

Effects of Silicon Dioxide Nanoparticles on Peripheral Nervous System Neural Cell Models

Jaiswal A.R., Lu S., Pfau J., Wong Y.Y.W., Bhushan A., Leung S.W., Daniels C.K., Lai J.C.K., Idaho State University, US

Cell model systems in vitro facilitate the high through-put screening of putative toxicity of a variety of nanomaterials, including nanoparticles. However, most of such cell models consisted of non-neural cells. We have developed several central [...]

Cytotoxic studies of PEG functionalized ZnO Nanoparticles on MCF-7 cancer cells

Rodriguez Martinez C., Ramirez Vick J.E., Perales O., Singh S.P., University of Puerto Rico-Mayagüez, US

Nanoparticles have shown great promise in biomedical applications. Zinc oxide (ZnO) nanoparticles are being explored for various applications such as sun screen lotion, antimicrobial properties, advanced textiles, photodynamic therapy and electronic devices. We have synthesized [...]

Mechanistic studies of in vitro cytotoxicity of PAMAM dendrimers in mammalian cells

Mukherjee S.P., Lyng F.M., Garcia A., Davoren M., Byrne H.J., Focas Research Institute, Dublin Institute of Technology, IE

The in vitro cytotoxic response of human dermal and colon cell lines to structurally well-defined full generation cationic dendritic polyamidoamine (PAMAM) nanoparticles of generations G4, G5, G6 was investigated. PAMAM dendrimers have been demonstrated to [...]

Cytotoxicity Assessment of Human Lung Alveolar Cell Exposed to Nanoparticles and Polycyclic Aromatic Hydrocarbons Exhausted from Motorcycle

Chien S.M., Huang Y-J, Chuang C.C.Y., Hsiao I.L., Kuo Y.F., National Tsing Hua University, TW

The potential harmfulness of traffic pollutants, particulate matter (PM) and polycyclic aromatic hydrocarbons (PAHs), were elevated with the increment of motocycles. However, the toxicology of the nanoparticulate and particle-PAHs (p-PAHs) has rarely been evaluated in [...]