cancer – Page 4 – TechConnect Briefs

Radiolabeling of Nanoshells with Cu-64 and In-111 for PET and SPECT Imaging in Rats

Xie H., Wang Z., Bao A., Goins B., Phillips W.T., Coleman C.L., Texas Southern University, US

Here we report for the first time the radioactive labeling of gold-silica nanoshells with Cu-64 and In-111. A bifunctional polyethylene glycol (PEG2000) is used as crosslinker to connect nanoshells with DOTA or DTPA, which are [...]

Ferromagnetic Resonance Biochip for Diagnosing Pancratic Cancer

Casler E., Chae S., Kunduru V., Bothara M., Yang E., Ghionea S., Dhagat P., Prasad S., Portland State University, US

The goal of this research is to be able to develop a device that would be able to detect and diagnosis pancreatic cancer at bedside. The key criteria to be addressed are the cost, portability, [...]

Phage Probes for Cancer Diagnostic and Treatment

Samoylova T.I., Morrison N.E., Cox N.R., Auburn University, US

Phage display is a powerful discovery tool with a variety of applications including identification of peptides that specifically recognize and bind to cell-surface targets. Phage particles carrying such peptides have the potential to serve as [...]

Organisation of peptide ligands on the surface of gene vectors

Wang M., Miller A.D., Thanou M., Imperial College London, UK

Through the considerate organisation of surface ligands, we have developed a lipid-based vector for the targeted delivery to cancer cells. Our ligand is a short peptide with high affinity for the Urokinase Plasminogen Activator receptor [...]

Multilayered ABCD Nanoparticles for siRNA delivery

Thanou M., Miller A., Imperial College London, UK

RNAi therapeutics represent a method to treat human diseases by addressing targets that are not possible to be addressed with conventional medicines. In our Centre we design nanosized systems for siRNA delivery that consist of [...]

Enrichment of serum phosphopeptide by nanoparticles to identify cancer biomarker

Shah A., Sachdev V., Bharti A., Boston University Medical School, US

The role of kinases in transformation and cancer progression is established. We hypothesize that The role the specific phosphoproteins/phosphopeptides will be present in cancer patient serum as leak proteins and their isolation and identification will [...]

Upconverting nanoparticles for photodynamic therapy

Chatterjee D.K., Zhang Y., National University of Singapore, SG

Photodynamic therapy involves killing of diseased cells by excitation of photosensitizer chemicals with high energy light to produce cytotoxic oxygen species from surrounding dissolved oxygen. However, poor tissue penetration of high energy light and hydrophobic [...]

Bacterial Drug Delivery Systems and nanoparticles

Sharma R., Haik Y., UNCG, US

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Glycosaminoglycan model glass substrates and cancer cell interactions

Peramo A., Wright G., Meads M.B., Dalton W.S., Matthews G., University of South Florida, US

The static adhesion of three cancer cell lines to surfaces functionalized with glycosaminoglycans was performed and the possible involvement of heparanase in this process was analyzed. Four different glycosaminoglycans (heparan sulfate, chondroitin sulfate A, chondroitin [...]

In vitro human model for tumor target screening in Cancer research

Mertsching H., Weimer M., Brunner H., Fraunhofer Institute of Interfacial Engineering and Biotechnology, DE

Monolayer and suspension cultures are still a highly artificial cellular environment for target screening and drug development. They have limited predictive value for target screening especially for nanomaterials. Target screening requires testsystems that mimic the [...]