cancer – TechConnect Briefs

Graphenoid plates in glioma therapy.

Grodzik M., Jagiello J., Jaworski J., Mandat T., Soltan E., Strojny B., Szczepaniak J., Wierzbicki M., Warsaw University of Life Sciences (WULS), PL

Glioblastoma multiforme (GBM) is a malignant primary tumour. The presence of necrotic areas and atypical vascularisation as well as the presence of atypical cells with nuclear pleomorphism and high proliferative ratio constitute the most important [...]

Functional Polylactide-based Systems for Delivery of Cancer Therapeutics

Chen C-K, Cheng C., Sun H., Yu Y., Zou J., University at Buffalo, the State University of New York, US

As an important class of biodegradable polymers, polylactides (PLAs) have been approved by FDA for clinical applications. However, conventional PLAs are lack of functionalities, and this significantly limits their applications. Therefore, in recent years we [...]

Titanate TiO2 Nanowire Bio-Scaffold as a Novel Sensor for Cancer Cell Differentiation

Alismail H., University of Arkansas, US

Human body cells undergo continuous division to compensate the cell loss in the body. This process is highly regulated and any abnormality can cause Cancer, which is a hot topic nowadays. Indeed, Cancer cell research [...]

Biosensor prototype based on carbon nanotubes for the RF-detection and NIR-treatment of HeLa cells

Avalos J., Caro G., García K., Morell G., University of Puerto Rico, US

The World Health Organization’s Annual Report on Cancer indicates that, in 2008, 12.4 million new cases and 7.6 million deaths from cancer alone were recorded around the world. Some of the treatments for HeLa cancer [...]

Branched PEI Capped Gold Nanoparticles in Water for siRNA Delivery to Cancer Cells

Biswas S., Guo J., Holmes J.D., O’Driscoll C.M., Rahme K., Notre Dame University (Louaize), LB

Herein we describe a simple method for the synthesis of different sizes of polyethylenimine-capped gold nanoparticles (AuNPs-PEI) in water and assess their potential to deliver siRNA or other therapeutic agents to cancer cells. AuNP-PEI with [...]

Artificial Bacteriophage for Anticancer Drug Delivery

Arce-Clavijo J.C., Espinosa-Duran J.M., Velasco-Medina J., UNIVERSIDAD DEL VALLE, CO

In this work, we present a new nanodevice, called artificial bacteriophage, name inspired in the Bacteriophage T4. The nanodevice is made up of two carbon nanostructures and molecular bioreceptors: 1) the nanocontainer, made of fullerenes [...]

Inhalable Stimuli-Responsive Theranostic Nanoparticles for Cancer in Deep Lung Tissue

Abbas Y.H., American University in Cairo, EG

Lung cancer is the deadliest solid tumour among all types of cancer. Despite advances in surgery and drug discovery lung cancer remains difficult to treat. This is a result of unavoidable exposure to carcinogens, poor [...]

Oxidized Graphene Nanoribbons as a Delivery System for the Bioactive Sphingolipid Ceramide

Sitharaman B., Suhrland C., Truman J.P., Stony Brook University, US

Dysregulation of the metabolic pathways of the sphingolipid ceramide has been shown to play key roles in cancer cell proliferation and survival. Targeting these pathways with exogenous modulators of ceramide metabolism such as the short [...]

Dielectrophoretic Isolation and Detection of Cancer Related DNA and RNA Nanoparticulate Biomarkers from Blood and Plasma

Heller M.J., Marciniak J., Skowronski E., Sonnenberg A., University of California San Diego, US

The analysis of cell free circulating (cfc) DNA and RNA nanoparticulate biomarkers continues to become more widely used for cancer diagnostics and management. Generally, cfc-DNA for “liquid biopsies” is isolated form plasma using relatively long [...]

Hybrid biosensor for the early diagnosis of breast cancer

Cho K., Chong S., Lee J-H., Park E., Luminescent MD, LLC, US

A cost-effective and novel hybrid biosensor using the combination of antibody and DNA aptamer was developed for the early diagnosis of breast cancer. 1,1’-oxalyldiimidazle chemiluminescence (ODI-CL) was applied as a detector of the hybrid biosensor. [...]