Brunner H. – TechConnect Briefs

In vitro testing of the penetration and permeation of nanomaterials on a artificial human skin model

Brunner H., Mertsching H., Weimer M., Fraunhofer Institute of Interfacial Engineering and Biotechnology, DE

We established a tissue engineered 3D human skin model. This interactive 3D-co-cultre consists of living human primary keratinocytes with a well-differentiated stratum corneum and an epidermal layer. The dermal layer is composed of a Type [...]

In vitro human model for tumor target screening in Cancer research

Brunner H., Mertsching H., Weimer M., Fraunhofer Institute of Interfacial Engineering and Biotechnology, DE

Monolayer and suspension cultures are still a highly artificial cellular environment for target screening and drug development. They have limited predictive value for target screening especially for nanomaterials. Target screening requires testsystems that mimic the [...]