cancer – Page 3 – TechConnect Briefs

Computational Modeling of Electromagnetically Induced Heating of Magnetic Nanoparticle Materials for Hyperthermic Cancer Treatment

Rast L., Harrison J.G., University of Alabama at Birmingham, US

We present results on the computational modeling of electromagnetically induced heating for the purpose of hyperthermic cancer treatment with magnetic nanoparticle fluids. Magnetic hyperthermia can therefore be used for direct targeting and destruction of tumors [...]

Zebrafish as a universal in vivo model for plasmonic nanoparticle medicine

Lukianova-Hleb E., Santiago C., Wagner D., Hafner J., Lapotko D., Rice University, US

In vivo application of plasmonic methods faces serious challenges because standard animal models are not well suited for optical activation and detection of plasmonic effects and for precise control the distribution and interactions of the [...]

Halloysite Clay Nanotubes: Characterization, Biocompatibility and Use as Drug Carriers

Vergaro V., Abdullayev E., Zeitoun A., Giovinazzo G., Santino A., Cingolani R., Lvov Y.M., Leporatti S., National Nanotechnology Laboratory (NNL) of CNR-INFM, IT

Halloysite nanotubes (HNTs) are efficient nano-containers capable of entrapping a range of active agents within the inner lumen, followed by their retention and slow release. Halloysite is a green environmentally friendly object available in commercial [...]

Nanocarriers for Cancer Therapy

Vergaro V., Zheng X., Zheng Z., Zheng X., Zheng Z., Lvov Y.M., Giovinazzo G., Santino A., Cingolani R., Rinaldi R., Leporatti S., National Nanotechnology Laboratory (NNL) of CNR-INFM, IT

Drug nano-colloids encapsulated by combination of layer by layer (LbL) techniques and ultrasonication, phytochemical encapsulated-artificial oleosomes and drug-loading clay nanotubes have been uptaken by neoplastic cells. Morpho- mechanical changes induced by such nanocarriers in living [...]

Detection of Cancer Related DNA Nanoparticulate Biomarkers and Nanoparticles in Whole Blood

Heller M.J., Krishnan R., Sonnenberg A., University of California San Diego, US

The ability to rapidly detect DNA nanoparticulate biomarkers and drug delivery nanoparticles directly in blood is a major challenge for early disease detection and nanomedicine. We now show that a microarray dielectrophoretic (DEP) device can [...]

Enhanced Cytotoxicity of Doxorubicin Conjugated to Ultrasmall Au Nanoparticles

Zhang E., Ntumba K., Nadeau J., McGill University, CA

In this study we find that ultra-small (mean diameter, 2.8 nm) Au nanoparticles conjugated to doxorubicin (Au-Dox) are up to five-fold more cytotoxic to B16 melanoma cells than Dox alone. The particles enter the cell [...]

From Micro- to Nano- Patterning: Manipulating the Extracellular Matrix and Directing Cell Organization, Migration & Adhesion

Moten A., Harvard Univeristy/Massachusetts Institute of Technology, US

Cells are inherently sensitive to local mesoscale and microscale patterns of chemistry and topography. Recent research has investigated how surface mechanics might dictate cell behavior, affecting both cell function and differentiation. This study professes that [...]

Method of LANTCET for cancer diagnostics and treatment at cell level

Hleb E.Y., Zastinskaya I.A., Ilyukova I.I., Semenenya I.N., Hafner J.H., Hanna E.Y., Myers J.N., Zhdanok S.A., Lapotko D.O., A. V. Lykov Heat & Mass Transfer Institute, BY

We have developed the method of LANTCET (laser-activated nano-thermolysis as a cell elimination technology) for selective detection and destruction of individual tumor cells by generating intracellular photothermal bubbles around the clusters of gold nanoparticles. Bare [...]

Role of Ultrasound in Anti-Cancer Drug Delivery Loaded on Microspheres

Mohamed M.M., El belbese M.A., Kotb M.A., Fikry N.M., Ramadan H.S., Alexandria University, EG

Targeting is a new therapeutic tool for malignant tumor as a result of combining nanotechnology with chemotherapeutics. Ultrasound has been shown to enhance degradation and drug delivery from biodegradable and non biodegradable polymeric devices. If [...]

Nanotube Biosensor Arrays for Detection of Molecular Surface Markers in Breast Cancer Cells

Panchapakesan B., Wickstrom E., University of Louisville, US

Recent reports have shown that nanoscale electronic devices can be used to detect a change in electrical properties when receptor proteins bind to their corresponding antibodies functionalized on the surface of the device, in extracts [...]