binding – TechConnect Briefs

Attenuated-Affinity Biotin Analogs for Catch-and-Release with Streptavidin

Corry S., Ying L-Q, Branchaud B., Life Technologies, US

The binding between streptavin and biotin, which is one of the strongest non-covalent interactions known in nature, is used ubiquitously in molecular biology. However, when a biotinylated molecule is captured for testing purposes and cannot [...]

Enhancement of E6 Protein Binding on Binding-Orientation-Sensitive Mixed SAMs Molecules

Tseng F-G, Tseng Y.T., Hwang J.K., Hung S.W., Chang J.M., Huang H.M., Huang T.W., Tseng F-G, Tseng Y.T., Huang H.M., Huang T.W., Chieng C-C, National Tsing Hua University, TW

Orientation selectivity and binding enhancement with E6 protein are demonstrated by nano-structured mixed-SAMs systems of different chain lengths. Mixtures of n-alkinethiol SAMs of different chain lengths: 1-Decanethiol (C9) and 1-Hexanethiol (C5) are the examples in [...]

Modeling of the Kinetics of Capture of Pathogens Enhanced by a Marangoni Flow

Pham P., Achard J.L., Berthier J., Ginot F., CEA-LETI, FR

Binding of targetted biomolecules, pathogens or analytes on a reactive surface is commonly used for biodiagnostic systems. However the process is slow and inefficient if one relies only on molecular diffusion to transfer the analytes [...]

Biochemical Binding in Microspheres-Based-Imunoassays

Prabhakarpandian B., Shah K.B., Sundaram S., Makhijani V.B., CFD Research Corporation, US

Microspheres (referred commonly as beads) are being extensively used in biochemical assays as supports for proteins, DNA, etc. We have successfully developed |omputational models for simulating sample detection using flowing beads. The model fully integrates [...]

Biochemical Binding in Microspheres-Based-Imunoassays

Prabhakarpandian B., Shah K.B., Sundaram S., Makhijani V.B., CFD Research Corporation, US

Microspheres (referred commonly as beads) are being extensively used in biochemical assays as supports for proteins, DNA, etc. We have successfully developed computational models for simulating sample detection using flowing beads. The model fully integrates [...]