angiogenesis – TechConnect Briefs

VEGF-dependent mechanism of anti-angiogenic action of diamond nanoparticles in glioblastoma multiforme tumor

Grodzik M., Sawosz E., Wierzbicki M., Hotowy A., Prasek M., Jaworski S., Chwalibog A., Warsaw University of Life Sciences, PL

Inhibition of tumor angiogenesis suppresses tumor growth and prevents metastasis, and is a key target in cancer therapy. Novel materials, nanoparticles of carbon allotropes (C60 fullerenes, graphite nanoparticles, multi-walled carbon nanotubes, single-walled carbon nanotubes and [...]

Nanoparticles co-encapsulating hVEGF and hAng-1 can induce mitotic and antiapoptotic effect on vascular endothelial cells

Khan A.A., Paul A., Abbasi S., Prakash S., McGill University, CA

This study demonstrates the combined effect of the angiogenic proteins, hVEGF and hAng-1, coencapsulated in human serum albumin (HSA) nanoparticles (NPs), towards human umbilical vein endothelial cells (HUVECs) and an evaluation of the potential application [...]

Development of Nanoconjugate with Different Monoclonal Antibodies to Inhibit Molecular Targets Important for Tumor Angiogenesis

Fujita M., Khazenzon N.M., Lee B-S, Holler E., Black K.L., Ljubimova J.Y., Cedars-Sinai Medical Center, US

Tumor cell-specific drug targeting is the major goal of nanotechnology-based platforms. A nanoconjugate Polycefin was synthesized for targeted delivery of antisense oligonucleotides and antibodies into tumors. The delivery of antisense oligonucleotides to α4 and β1 [...]