Berthier J. – Page 2 – TechConnect Briefs

On the dynamic contact angle in spontaneous capillary flow

Berthier J., Gosselin D., Delapierre G., CEA-LETI, FR

Capillary actuation of fluids is an interesting solution when the gravitational forces are small: this is the case in space , or in microfluidic systems where gravity is negligible. The onset of spontaneous capillary flow [...]

Recent advances in capillary microflows for point-of-care and home-care devices

Berthier J., Gosselin D., Huet M., Cubizolles M., Delapierre G., CEA/LETI/MINATEC, FR

Biotechnology has been recently seeing fundamental evolutions: first, a clear shift towards biological applications; second a trend towards the design and fabrication of portable devices; third the choice of inexpensive materials such as plastic or [...]

Determination of the bi-substrate kinetic coefficients for the beta-D-glucose- NAD-GDH enzymatic reaction

Berthier J., Cubizolles M., Laurent P., Pouteau P., Poher V., Cosnier M.L., CEA, FR

Colorimetric detection of glucose in sample liquids such as human plasma is made by using enzymatic reactions. In the multi reactional scheme, the first enzymatic reaction is determinant. Either glucose oxidase (GOX) or glucose dehydrogenase [...]

Open-Surface Microfluidics

Berthier J., Brakke K.A., Furlani E.P., Karampelas I.H., Delapierre G., CEA-LETI, FR

The developments of open-surface microfluidics (OSM) for biotechnology are recent, and motivated by the development of point-of-care (POC) and home-care systems. The advantages of capillary systems are (1) low cost due to easy and fast [...]

On the velocity of spontaneous capillary flows in confined and open microchannels

Berthier J., Villard N., Pudda C., Boizot F., Nonglaton G., Costa G., Fontelaye C., Delapierre G., CEA-LETI, FR

In biotechnology and biology, conventional microfluidic systems using fluids moved by pumps, syringe or electric means are not the best solutions when portability and low-cost are an issue. Capillary-based systems fulfill the requirements for POC [...]

From Microfluidics for Biotechnology to Biomicrofluidics

Berthier J., CEA-LETI, FR

In the biotechnology science, microfluidics is constantly adapting to the goals of biologists. Once a precise goal has been identified, biotechnology is searching for the best approaches to meet the demand of biologists. These approaches [...]

New microfluidic chip for the production of spherical gelled capsule for cell encapsulation

Dalle P., Morales S., Berthier J., Benhamou P-Y., Bellemin Comte A., Boizot F., Costa G., Rivera F., CEA-LETI, FR

Implantation of Langerhans islet in alginate shell is an alternative for the treatment of diabetes type 1. Finding an adapted process for cell encapsulation is a challenge. The process must product spherical and monodisperse capsules [...]

A Model for Enhanced Chemiluminescence Reactions in Microsystems

Berthier J., Joly P., Rivera F., Caillat P., CEA-LETI, FR

Detection of hybridized targets—like DNA strands—in microsystems for biotechnology is usually done by fluorescence. However, recent investigations have shown that chemiluminescence could be a more effective and sensitive tool for detection under the condition that [...]

Self-alignment of Silicon Chips on Wafers: the Effect of Spreading and Wetting

Berthier J., Brakke K., Sanchez L., Di Cioccio L., CEA-LETI, FR

3D integration appears as the key to advanced microelectronic systems. While robotic methods experience difficulties to accommodate fabrication speed and alignment accuracy, self-assembly methods are promising due to their parallel aspect, which overcomes the main [...]

The Physics of Pressure Powered Micro-Flow Focusing Device for the Encapsulation of Live Cells

Berthier J., Dalle P., Rivera F., Renaudot R., Morales S., Benhamou P-Y., Caillat P., CEA-LETI, FR

Flow focusing devices (FFD) have emerged as a powerful tool for cell encapsulation and formation of micro-emulsions [1,2]. In the frame of live cell encapsulation, a micro-FFD using alginate solutions for the capsule and powered [...]