CFD Research Corporation – Page 5

Computational Design Analysis for In-Plane Microfluidic Valves

Dickey C.K., Makhijani V.B., Deshmukh A., Liepmann D., CFD Research Corporation, US

Simulations of fluid flow across in-plane microvalves were performed using an advanced multi-physics commercial software system and compared with experimental data. Model validation required careful consideration of leakage pathways left by fabrication artifacts. Following model [...]

Electrodynamic Transport, Electroporation and Lysis of Cells in Pharmacological and Bioanalytical Microsystems

Przekwas A.J., Chen Z.J., Athavale M., CFD Research Corporation, US

Biological information is stored in cells and is the prime object of interest of pharmacological, biomedical, and bioanalytical professionals. Whatever the interest: elcectroporative drug delivery and pharmacodynamics, in vivo PCR, infection pathology, DN

Analysis of Sample Transport in Capillary Electrophoresis Microchip Using Full-Scale Numerical Analysis

Krishnamoorthy S., Feng J.J., Makhijani V.B., CFD Research Corporation, US

An implicit finite-volume numerical scheme has been developed to solve the three-dimensional transport equations along with fully-coupled ionization equilibria in acid/base systems. The scheme solves conservation equations for mass and momentum while satisfying the electroneutrality [...]

Mixed-Dimensionality, Multi-Physics Simulation Tools for Design Analysis of Microfluidic Devices and Integrated Systems

Przekwas A.J., Makhijani V.B., CFD Research Corporation, US

Computational design of microfluidic devices and integrated microsystems involves several strongly coupled physical disciplines, including fluid mechanics, heat transfer, stress/deformation dynam-ics, electrokinetics, biochemistry and others. CFDRC is dev

A Computational Framework for Modeling One-Dimensional, Sub-Grid Components and Phenomena in Multi-Dimensional Micro-Systems

Pindera M.Z., Bayyuk S., Upadhya V., Przekwas A.J., CFD Research Corporation, US

This paper presents a framework for modeling essentially one-dimensional devices and components embedded in multi-dimensional spaces. The main characteristic and main advantage of the new methodology is that the one-dimensional and multi-dimensional objects or domains [...]

CFD-Micromesh: A Fast Geometrical Modeling and Mesh Generation Tool for 3D Microsystem Simulations

Tan Z., Furmanczyk M., Turowski M., Przekwas A.J., CFD Research Corporation, US

In this work, a new fully automated geometrical modeling and meshing tool is described. It imports standard layout formats (CIF, GDSII, DXF), images (GIF, JPG), and 3D boundary representations (STL). A 3D model is then [...]

High-Fidelity and Reduced Models of Synthetic Microjets

Przekwas A.J., Turowski M., Chen Z., CFD Research Corporation, US

Microfabricated arrays of synthetic jets are being explored for applications in aerodynamic flow control, in cooling of electronic packages, and in mixing in microchemical reactors. Computational simulation of coupled unsteady fluid mechanics and electromechanical actuation [...]

Computational Studies of Membrane-Based Test Formats

Krishnamoorthy S., Makhijani V.B., Lei M., Giridharan M.G., Tisone T., CFD Research Corporation, US

Membrane-based test formats provide simple, accurate and cost effective diagnoses of acute and chronic conditions in general population health. The sensitivity of the immunoassay is determined by the complex biochemical binding kinetics associated with the [...]

Analysis of Sample Injection and Band-Broadening in Capillary Electrophoresis Microchips

Krishnamoorthy S., Giridharan M.G., CFD Research Corporation, US

An implicit finite-volume numerical scheme has been developed to solve the three-dimensional transport equations that govern the electroosmotic and electrophoretic phenomena. The scheme consists of solving the ion transport equation and electro-neutrality condition coupled with [...]

Coupled Fluid-Thermal-Structural Simulations in Microvalves and Microchannels

Athavale M.M., Yang H.Q., Przekwas A.J., CFD Research Corporation, US

This paper presents the results of high-fidelity, 3-D simulations of coupled flow, heat-transfer and structural mechanics simulations of microchannels, micropumps, microvalves, and time-accurate simulations of a microoscillator. In each of these cases, the simulated results [...]