CFD Research Corporation – Page 3

Resolved Particle Simulations of Microsphere/Cell-based Bioanalytic Systems

Pant K., Romanowicz B.F., Sundaram S., CFD Research Corporation, US

Microsphere and cell-based assays are emerging as the platform of choice for rapid quantitation of biomolecular interactions in bioagent detection, clinical diagnosis, drug therapy, etc. [1,2] Traditional assay designs have been driven by expensive trial-and-error [...]

A Fokker-Planck Approach For Modeling Integrated NanoBio Systems

Jenkins J.W., Sundaram S., CFD Research Corporation, US

Physics-based, high-fidelity simulations have emerged as indispensable tools in the design of complex, microfluidic devices (lab-on-chip). However, ab-initio analysis becomes increasingly complicated as the dimensions of the device approach nanoscales and molecular information/interactions must be [...]

Quantum and Kinetic Simulation Tools for Nano-scale Electronic Devices

Fedoseyev A., Kolobov V., Arslanbekov R., Przekwas A., Balandin A., CFD Research Corporation, US

The progress in LSI technologies has resulted in scaling down semiconductor devices to nano-scale dimensions where kinetic and quantum effects in the carrier transport become crucial for the device performance. The transistor counts on the [...]

Coupled Multiphysics Modeling of Semiconductor Lasers

Sikorski Z., Jiang Y., Czyszanowski T., Przekwas A., Turowski M., CFD Research Corporation, US

Comprehensive models of semiconductor lasers are required to predict realistic behavior of various laser devices for the spatially nonuniform gain that results due to current crowding. Nonuniform gain has visible effect on laser dynamics and [...]

Numerical Simulation of Field Amplified Sample Stacking in Microfluidic System

Feng J.J., Krishnamoorthy S., Sundaram S., Bhardwaj R., Santiago J.G., CFD Research Corporation, US

In this paper we developed a numerical simulation method that solves the transport phenomenon associated with sample stacking in microchip-based separation system. The model is based on thin double layer approximation where the electrostatic force [...]

Numerical Simulation of Electroosmotic Flow in Micro Channels with Analytical Integration of Surface Potential

Chen Z., Athavale M., Przekwas A., CFD Research Corporation, US

We have developed a new methodology to simulate electroosmotic flows in micro channels, which allows us to accurately produce the effects of the double layer without resolving it. The method is a subgrid type model [...]

A Fokker-Planck Approach For Modeling Integrated NanoBio Systems

Jenkins J.W., Sundaram S., CFD Research Corporation, US

Physics-based, high-fidelity simulations have emerged as indispensable tools in the design of complex, microfluidic devices (lab-on-chip). However, ab-initio analysis becomes increasingly complicated as the dimensions of the device approach nanoscales and molecular information/interactions must be [...]

Coupling between Nanoscale and Microscale Modeling for MicroFluidic Devices

Jenkins J.W., Sundaram S., Makhijani V.B., CFD Research Corporation, US

Evaluation of microfluidic device and sensor designs using continuum modeling is a valuable method, but becomes more complex if nanoscale or molecular level physics must be included in the model. Recently, we have undertaken an [...]

Biochemical Binding in Microspheres-Based-Imunoassays

Prabhakarpandian B., Shah K.B., Sundaram S., Makhijani V.B., CFD Research Corporation, US

Microspheres (referred commonly as beads) are being extensively used in biochemical assays as supports for proteins, DNA, etc. We have successfully developed |omputational models for simulating sample detection using flowing beads. The model fully integrates [...]

Numerical and Analytical Studies of AC Electric Field in Dielectrophoretic Electrode Arrays

Feng J.J., Krishnamoorthy S., Chen Z.J., Makhijani V.B., CFD Research Corporation, US

Manipulation of micro-sized particles and biological cells using dielectrophoresis (DEP) is an emerging technique in MEMS and nano technology[3]. This paper presents an exact solution of dielectrophoretic motion of a polarized particle in the vicinity [...]