US – Page 374 – TechConnect Briefs

Inkjet Assisted Micro-Scale Cooling of Electronics

Sharma R.K., Bash C.E., Patel C.D., Hewlett Packard Co. Laboratories, US

Rise in the overall power dissipation of computer systems has posed a severe challenge for cooling microprocessors. Increases in microprocessor power dissipation and the resulting effect on the cost and complexity of thermal management solutions [...]

Hyperselective and Targeted Separation of Analytes Using Multiple Dynamic Equilibrium Gradients Approach

Markushin Y., Dawoud A., Jankowiak R., Ames Laboratory USDOE, US

There is a growing need for compact and reliable advanced microfluidic devices and/or adapters for conventional capillary electrophoresis (CE) that can provide an improved resolving power of analytes. It is demonstrated that separation of analytes [...]

Nanofilament Directional Control within a Hybrid Microelectronic Actin-Myosin Motility Assay via Integrated Electric Field Addressing

Famouri P., Takatsuki H., Hornak L.A., Brown K., Chilakamarri R., Timperman A., Lenke J., Gannett P., Kohama K., West Virginia University, US

Control of biomolecular transport is essential to the advancement of nanokinematic systems whether for molecular cargo delivery in sensing or assembly processes, or as a means to interface micro-electro-mechanical systems with the nanoscale regime. Actin-myosin [...]

Enhanced Separation Performance in Microfabricated Electrophoresis Devices by Electric Field Induced Collection and Metering of DNA

Shaikh F.A., Ugaz V.M., Texas A&M University, US

Microfluidic technology is a key component in the development of microfabricated lab-on- a-chip systems for use in bioanalytical and biosensing applications. These devices continue to be developed to perform a variety of DNA analysis assays, [...]

Accurate High-throughput Gene Synthesis Using Programmable DNA Microfluidic Microchips

Tian J., Gong H., Sheng N., Zhou X., Gulari E., Gao X., Church G.M., Harvard Medical School/Genetics, US

Testing the deluge of hypotheses flowing from genomics and systems biology demands accurate and cost-effective gene and genome synthesis. Here we describe a microchip-based technology for multiplex gene synthesis. Pools of thousands of "construction" oligonucleotides [...]

Fast DNA Immobilization and Hybridization on a CD (Compact Disc) Microfluidic Platform

Jia G., Ma K-S, Madou M.J., Kido H., Zoval J.V., Madou M.J., University of California at Irvine, US

A CD-based flow-through approach for DNA immobilization on gold surfaces was proposed and validated using 25-mer thiol-derivatized nucleotides (T-SH) labeled with fluorescent (Cy3) dye. Amino-derivatized ssDNA (T-amino) of the same sequence was used as a [...]

Rapid DNA Amplification in Buoyancy Driven Closed Loop Microfluidic Systems

Agrawal N., Ugaz V.M., Texas A&M University, US

Buoyancy driven fluid motion, however, can also occur in closed loop geometries in response to either vertically or horizontally imposed temperature gradients. These systems offer the exciting possibility of generating unidirectional laminar flows along a [...]

Microfluidic Injector Models Based on Neural Networks

Magargle R., Hoburg J.F., Mukherjee T., Carnegie Mellon University, US

An injector modeling methodology based on neural networks is presented. The new aspects of this approach are (1) the full description of the dynamic injector behavior and (2) the applicability of the approach to a [...]

High Sensitivity, Microfluidic Immunoassays utilizing DNA-conjugated Antibodies to Accelerate the Electrophoretic Separation of Antigen-Antibody Complexes

Wada H.G., Kawabata T., Kazakova I., Simeonov A., Park C., Kechagia P., Spaid M., Watanabe M., Satomura S., Wako Pure Chemical Industries Ltd., US

The promise of microfluidic immunoassays in microchips has been the miniaturization, integration and automation of rapid immunoassays. The typical microfluidic assays have used fluorescent dye labeled antibodies in direct binding assays or labeled antigens in [...]

Electrokinetic Instabilities and Sample Stacking

Lin H., Oddy M.H., Santiago J.G., Stanford University, US

Microfabrication technology has enabled the application of electrokinetics as a method of performing chemical analyses and achieving liquid pumping in electronically-controlled microchip systems with no moving parts. This talk reviews progress at Stanford in the [...]