US – Page 336 – TechConnect Briefs

A Continuous Particle/Cell Sorter Using Dielectrophoresis

Wang G.R., Feng J.J., Vasantgadkar S., Pant K., Prabhakarpandian B., Krishnamoorthy S., Sundaram S., CFD Research Corporation, US

We present a novel design of a continuous microfluidic sorter for separation of cells or particles by the intelligent use of conventional negative dielectrophoresis with separation efficiency of greater than 95%. A high fidelity modeling [...]

Optimizing antibody microarrays for high resolution SPR microscopy

Kim G., Nishimoto A., Cong S., Johnson E., Guan H.W., Petcavish B., Lasky S., Hood L., Campbell C.T., Lumera Corporation, US

A high resolution surface plasmon resonance (SPR) microscopy technique based on the combination of Lumera’s polymer and proprietary optic technologies offers parallel high-throughput analysis of biomolecular binding kinetics on high-density antibody microarrays ( > 1,500 [...]

Compact Disc (CD)-Based Automated Animal Assay

Kim N.H., Dempsey C.M., Zoval J., Sze J.Y., Madou M.J., University of California Irvine, US

Microfabricated platforms that allow automated cultivation and behavioral observation of Caenorhabditis elegans would be a valuable tool in physiological and genetic studies. Here, we report an automated microfluidic compact disc (CD) system conducive to the [...]

Mixed-Methodology-Based System-Level Simulation of Biochemical Assays in Integrated Microfluidic Systems

Wang Y., Bedekar A.S., Krishnamoorthy S., Siddhaye S.S., Sundaram S., CFD Research Corporation, US

While lab-on-a-chip (LoC) systems are increasingly used in the areas of genomics, proteomics and drug discovery, their efficient simulation and design at system-level continue to be a challenge. Experimental trial-and-error and multiphysics-based high fidelity computation [...]

Coin-Shaped Reactor in Microfluidic Devices Used for Radiopharmaceutical Synthesis

Elizarov A.M., Kolb H.C., van Dam R.M., Heath J.R., Padgett H.C., Huang J., Daridon A., California Institute of Technology, US

A microfluidic device designed and optimized for the multi-step synthesis of PET (Positron Emisssion Tomography) probes is presented. It is the first device in its class to produce radiopharmaceuticals of sufficient quality and quantity (over [...]

Integrated microfluidic device to monitor the cells acidification rate in nanoliter volumes using microfabricated iridium oxide electrodes

Ges I.A., Ivanov B.L., Baudenbacher F.J., Vanderbilt University, US

In our work we describe a new approach to measure pH differences in microfluidic devices and demonstrated acidification rate measurements in on-chip cell culture systems with nanoliter wells. We used two miniaturized identical iridium oxide [...]

Thermally Induced Marangoni Instability of Liquid Microjets with Application to Continuous Inkjet Printing

Furlani E.P., Price B.G., Hawkins G., Lopez A.G., Eastman Kodak Co., US

Liquid microjets are inherently unstable and can be broken into droplets in a controllable fashion via thermal modulation of surface tension. Such modulation can be achieved using CMOS/MEMS technology by integrating resistive heating elements around [...]

Electric Field Driven Motion of Flexible Polyelectrolytes – A Molecular Dynamics Study

Lo T.S., Khusid B., Acrivos A., Koplik J., New Jersey Institute of Technology, US

Our work aims to develop multi-scale computational procedures for simulating the dielectrophoretic behavior of biomolecules in micro- and nano-electrofluidics, which combine electrohydrodynamics with molecular theories for the macromolecule polarization caused by the distortion of the [...]

Simulation of Electrokinetic Flow and Analyte Transport in Nano Channels

Feng J.J., Krishnamoorthy S., Wang G.W., Sundaram S., CFD Research Corporation, US

This paper demonstrates the electrokinetic flow and transport of charged and neutral analytes in nanochannels by solving full system of governing Poisson-Nernst-Planck equations without any assumptions. The issues related to the spatial and time scales [...]

Superhydrophobic Nanowire Surfaces for Drop Movement Using Magnetic Fields

Egatz-Gomez A., Melle S., García A.A., Lindsay S., Rubio M.A., Domínguez P., Picraux T., Taraci J., Clement T., Hayes M., Gust D., Arizona State University, US

We present a novel method to control water drop movement on superhydrophobic surfaces through magnetic fields. Water drops with paramagnetic particles can be moved on fractal Si-nanowire superhydrophobic surfaces at high speeds by displacing a [...]