US – Page 335 – TechConnect Briefs

A Micromachined Sparse Cell Isolation Device: Application in Prenatal Diagnostics

Mohamed H., Turner J.N., Caggana M., Wadsworth Center, New York State Department of Health, US

The isolation of fetal cells from maternal circulation is the subject of intense research. Fetal cells can be isolated using several enrichment methods, however no technique to specifically isolate and use them for genetic diagnosis [...]

Synthesis of Shear Thickening Fluid Using Sonochemical Method

Rangari V.K., Hassan T.A., Mahfuz H., Jeelani S., Tuskegee University, US

Shear thickening fluid is developed using sonochemical method which one step process and can be processed from its dry metal oxide powder forms instead of its colloidal solution. The main problem with the current process [...]

Microfluidics and Rheology of Carbon Black Dilute Suspensions: Modeling, Measurement, and Applications

Aramphongphun C., Hemminger O., Castro J.M., Lee L.J., The Ohio State University, US

Rheology and microfluidics are essential and challenging topics in designing microfluidic devices and materials processing. A study of rheological properties (e.g. viscosity) of complex fluids becomes more important in the flow at microscale due to [...]

Microfluidic Device for Conventional and Traveling-Wave Dielectrophoresis

Kumar A., Acrivos A., Khusid B., James C.D., New Jersey Institute of Technology, US

Conventional and traveling-wave dielectrophoresis in suspensions are proven techniques for the manipulation, separation, and characterization of suspended particles with potential applications ranging from biological warfare agent detection to healthcare industry. In contrast to previous studies, [...]

Shape Oscillation and Internal Mixing in Sessile Liquid Drops using ElectroWetting-On-Dielectric (EWOD)

Miraghaie R., Sterling J.D., Nadim A., Keck Graduate Institute, US

We show that internal mixing within a sessile liquid drop can be significantly enhanced by means of so-called electrowetting-on-dielectric (EWOD), using an alternating electric potential. This is done experimentally by comparing the coalescence and mixing [...]

Computational experiments on three-dimensional molecular diffusion in porous media

Alarcon V.J., Kingery W., Zhu J., Mississippi State University, US

Estimations of apparent diffusion coefficients usually consist of curve-fitting the output of one-dimensional models to experimental laboratory-measured data from porous aggregates shaped in different forms. In this research a computational exploration is presented on the [...]

Simulation of a Microfluidic Particle Concentrator and Separator

Chen C.C., Auner G.W., Industrial Technology Research Institute, TW & Wayne State University, US

A flow-through micro polymerase chain reaction (PCR) chip was optimized by using coupled multiphysics computational tools. Comprehensive simulations of temperature and flow profiles were presented for the denaturation, extension, and annealing zones on the flow-through [...]

Simulation and Optimization of a Flow-Through Micro PCR Chip

Kang J., Chen C.C., Smolinski J., Thomas R.A., Tucker J.D., Auner G.W., Industrial Technology Research Institute, TW & Wayne State University, US

We present a microfluidic particle concentrator and separator employing a large flow unit array. Each flow unit includes a nozzle, a sharp turn, a diffuser, and a flow dividing segment. After acceleration in the nozzle, [...]

Computationally Efficient Models of Flow-through Affinity-based Assays

Peterson D.K., Wright W.H., MacQueen D.B., SRI International, US

Lateral flow “strips” are a common assay format used in a variety of applications, including home pregnancy testing, clinical point-of-care screening for HIV, agribusiness surety against pathogens, and military bioagent detection. Current lateral flow assays [...]

Microchannel Mixing, Entropy and Multifractals

Kaufman M., Camesasca M., Manas-Zloczower I., Cleveland State University, US

Microfluidic systems operate in a pressure driven flow regime with no moving parts to drag the fluids. Our research aims at developing rigorous assessment and quantification tools of mixing in microchannels. The tools are based [...]