US – Page 199 – TechConnect Briefs

Nanoparticles that facilitate imaging of biological tissue and methods of forming the same

Sharma R., Florida State University, US

A superparamagnetic nanoparticle (SPIOM) containing antimyoglobin coated and polyethylene encapsulated biotin-avidin-iron-oxide core in center may be provided according to an example in the invention. These nanoparticles may be used as imaging contrast agents due to [...]

Plasmonic Nanobubbles: tunable and transient probes for cancer diagnosis, therapy and theranostics

Lukianova-Hleb E., Drezek R., Hafner J., Lapotko D., Rice University, US

We report a tunable theranostic probe that can support the diagnosis, therapy and therapy guidance in one process in individual cancer cells. This probe is a plasmonic nanobubble (PNB), which is not a particle but [...]

Multi-Modal Superparamagnetic Nanoprobe: Harnessing Magnetic, Nuclear, and Optical Power for Diagnostic Imaging Applications

Bumb A., Regino C.A.S., Bernardo M., Dobson P.J., Choyke P., Brechbiel M.W., National Cancer Institute, US

Accurate characterization of the first draining sentinel lymph nodes in primary tumors is a challenging task where current methods rely on nodal size as the primary yardstick for differentiating benign from malignant nodes. Other parameters [...]

Qdot® nanocrystals in intracellular flow: ZAP-70, KI-67 and five-colors fluorophores panel

Sotnikov I., Jaron S., Konopleva M., O’Brien S., Andreeff M., Hildebrant J., Manis J., Brown J., Vorobjev I., Barteneva N., Immune Disease Institute, Harvard Medical School, US

We present, for the first time, the methodological approach for the measurement of cytoplasmic Zap-70 and nuclear Ki-67 proteins with Qdot® nanocrystals-labeled antibodies. Mononuclear cells from chronic lymphoid leukemia patients were used to detect Zap-70, [...]

Zebrafish as a universal in vivo model for plasmonic nanoparticle medicine

Lukianova-Hleb E., Santiago C., Wagner D., Hafner J., Lapotko D., Rice University, US

In vivo application of plasmonic methods faces serious challenges because standard animal models are not well suited for optical activation and detection of plasmonic effects and for precise control the distribution and interactions of the [...]

Multimodality therapy: Enhancement of melanoma cell death with combination of heat shock protein 90 inhibitor, 17-(Allylamino)-17-demethoxygeldanamycin (17-AAG), and gold nanoparticles in a noninvasive radiofrequency field

Kaluarachchi W.D., Curley S.A., M.D. Anderson Cancer Center, US

Melanoma is the most deadly form of skin cancer. Hyperthermia has been used to treat advanced stage melanoma. However, solid tumors often respond minimally to hyperthermic treatment due to the thermo-tolerance induced by chaperons of [...]

Anti-K-Ras siRNA to Treat Pancreatic Cancer

Julien D.C., Giri A., Papasani M., Murdoch G., Hrdlicka P., Hill R.A., University of Idaho, US

Cancer of the pancreas is a leading cause of cancer-related mortality. Chemotherapeutic drugs used to treat pancreatic cancers are toxic and minimally effective, yielding a 1-4% 5-year survival rate after initial diagnosis. Approximately 90% of [...]

Bioluminescent Model for the Quantification of Photothermal Ablative Breast Cancer Therapy Mediated by Near-Infrared Nanoparticles

Gutwein L.G., Singh A.K., Hahn M.A., Rule M.C., Brown S.C., Moudgil B., Grobmyer S.R., University of Florida, US

Multifunctional nanoparticles hold promise for enabling non-invasive image guided cancer therapy such as photothermal therapy. Human breast tumor models in which response to image guided therapy can quickly and non-invasively be determined are needed to [...]

Targeting tumor associated macrophages using clodronate-loaded PLGA nanoparticles

Sharma G., Karmali P., Ramirez M., Xie Hui, Ruoslahti E., Smith J., Burnham Institute for Medical Research, US

There is increasing evidence now that tumor associated macrophages (TAMs) play a key role in tumor growth and metastasis by promoting tumor angiogenesis. Macrophages are also prominent in tumor tissues, comprising up to 80% of [...]

Combining gene therapy and nanomedicine to enhance the therapeutic potential of T cells

Choi Y., Torikai H., Lee D.A., Lee D.Y., Li K.C., Li Z., Lo D., Qin G., Tung C.H., Tasciotti E., Raphael R., Biswal S.L., Ang S., Lee D.A., Lee D.Y., Li K.C., Li Z., Cooper L.J.N., M.D. Anderson Cancer Center, US

we have developed a high throughput electroporator (HiTE) to manipulate large numbers (~10^9) of T cells ex vivo for clinical uses. HiTE is designed to electro-transfer RNA species to redirect T-cell specificity and gold nanoparticles [...]