US – Page 147 – TechConnect Briefs

Uptake and Elimination Behaviors of Polyethyleneimine (PEI)-Coated Multi-Walled Carbon Nanotubes by Eisenia Foetida and Daphnia Magna

Petersen E.J., Pinto R.A., Mai D.J., Landrum P.F., Zhang L., Huang Q., Shi X., Weber Jr W.J., National Institute of Standards and Technology, US

Hyphenated mass spectrometry (gas chromatography/mass spectrometry) techniques have been employed as one of the primary analytical tools for investigating the effects of ionizing radiation, chemical/biological carcinogens and oxygen derived free radicals on the induction and [...]

Nanomaterial Registry: An authoritative resource for assessing environmental and biological interactions of nanomaterials

Ostraat M.L., Mills K., Murry D., Guzan K., RTI International, US

Assessing the interactions of nanomaterials with environmental and biological systems is both complex and rapidly evolving. The complexity of these interactions arises from the fact that they are not only a function of the system [...]

Ceria Nanopartciles Reduce Disease Severity in a Mouse Model of Multiple Sclerosis

DeCoteau W., Heckman K., Reed K., Erlichman J.S., St. Lawrence University, US

Multiple sclerosis affects 300,00 people in the United States alone with 400 additional cases diagnosed each week. The first phase of the disease , is a relapse-remitting period where the patients symptoms wax and wane [...]

Molecular Changes in Rat Brain Due to Air Nano Pollution

Ljubimova J.Y., Gangalum P.R., Portilla-Arias J., Patil R., Konda B., Paff M., Markman J., Inoue S., Espinoza A., Chesnokova A., Kleinman M., Holler E., Black K.L., Cedars-Sinai Medical Center, US

Air pollution has been found to cause neurodegeneration, deposition of heavy metals & beta amyloid plaques in the brain. Air pollution constitutes of nanopollutant of different sizes that can enter the system and cause diseases. [...]

Cardiomyocyte Function on Poly-Lactic-co-Glycolic Acid: Carbon Nanofiber Composites under Electrical Stimulation

Stout D.A., Webster T.J., Brown Univeristy, US

In recent research, it was demonstrated that the use of nano-materials can promote the growth of cardiomyocytes when compared to the use of conventional or micro-structured materials. One such nano-material consisted of poly-lactic-co-glycolic acid (PLGA) [...]

Smaller sizes of Ag-PVP Nanoparticles Control Inflammatory Responses, and Reduce CD80 and CD86 Expression Levels, in Macrophages Infected with Chlamydia trachomatis

Yilma A.N., Singh S.R., Dennis V.A., Alabama State University, US

Chlamydia trachomatis is an important cause of sexually transmitted infection that can manifest itself as either acute cervicitis, pelvic inflammatory disease, and more commonly as a chronic asymptomatic infection. Early intervention strategies that can reduce [...]

Targeted Cancer Therapy by Immunoconjugated Gold-Gold Sulfide Nanoparticles Using Protein-G as a Cofactor

Sun X.H., Zhang G.D., Patel D., Gobin A.M., University of Louisville, US

Gold-gold sulfide nanoparticle (GGS-NP) with controllable near infrared (nIR) absorption was synthesized from a simple reaction of chloroauric acid and sodium thiosulfate. Through PEGylated recombinant Protein-G (ProG), ProG-conjugated GGS-NPs for antibody capture by Fc domain [...]

Supermagnatic Iron Oxide Nanoparticles Toxicity to Mammalian Cells

Vig K., Tiwari P., Parveen A., Rangari V., Singh S.R., Alabama State University, US

The present study investigates the development of superparamagnetic iron oxide nanoparticles as a controlled release drug formulation and use as anticancer therapeutic agents. Iron oxide nanoparticles (IONPs) were synthesized using ultrasonic irradiation of iron pentacarbonyl [...]

Polymalic acid-based nanodrugs: Anti-tumor efficacy and host compatibility

Holler E., Ding Hui, Patil R., Portilla J., Inoue S., Gangulum P., McNeil S.E., Patri A., Dobrovolskaia M.A., Black K.L., Ljubimova J.Y., Cedars-Sinai Medical Center, US

A polyanionic drug carriers is presented that penetrates biobarriers and targets molecular cancer markers of human breast and brain cancer. The carrier platform is poly(beta-L-malic acid) (PMLA), which is highly water soluble and biodegradable to [...]

A Nanopore Biomimetic Device Quantitatively Detects Early Stage Cancer Cells; a Contour Map Multiple Variable Correlation Method Assesses the Heat of Cancer Cells Released

Chen E.T., Shen J. Thornton Y., Ngatchou C., Duh S-H, Kissinger P.T., Advanced Biomimetic Sensors, Inc., US

Detecting low abundance cancer cell is challenged by the complex instrumentation and time consuming assays. We report a unique cancer cell detection device that is capable of detecting low abundance MDA-MB-231 breast cancer cells based [...]