US – Page 148 – TechConnect Briefs

Encapsulation and Characterization of BSA in PLA-PEG Nanoparticles as a Model for Chlamydia trachomatis rMOMP-278 Protein Nanovaccine Delivery System

Taha M., Singh S.R., Moore C., Agee R., Dennis V.A., Alabama State University, US

Chlamydia trachomatis is a major human health pathogen because it is the most reported sexually transmitted disease. There is no effective mucosal vaccine against Chlamydia. One of the major problems of the C.trachomatis vaccine development [...]

Designing Responsive Materials with Chemically Amplified Sensitivity to NIR light

Fomina N., McFearin C., Sermsakdi M., Morachis J., Almutairi A., University of California at San Diego, US

We employ near infrared (NIR) light as an external trigger for controlled material degradation and targeted release of a payload. NIR light can penetrate through tissues to an appreciable depth without scattering or damaging it. [...]

Surfactant Effect on Intercellular Transport of DNA, Proteins, and Electrolytes

Assan D., Gao X., Lai J.C.K., Leung S.W., Idaho State U, US

Surfactants play a key role on bodily functions at molecular level, such as cell signaling and signal transmission. Their importance in cell survival is well recognized, but the surfactant effect on intermolecular/interfacial mass transport is [...]

Development of PHEMA-Chitosan nanospheres and encapsulation of RSV-F DNA vaccine

Eroglu E., Waffo A.B., Dennis V.A., Singh S.R., Alabama State University, US

Respiratory Syncytial Virus (RSV) causes serious lower respiratory tract diseases among infants. Unfortunately, no effective vaccine to prevent RSV infection has been developed. RSV fusion gene (RSV-F) is conserved among various strains of RSV. Therefore, [...]

Controlled- Release Antibiotic Nanoparticles for Cranial Transplantation and Bone Grafting

Adusumilli A.N., Dammalapati S., Fu P.K.-L., Governors State University, US

The objective of this research is to develop a unique nanoparticulate system that is capable of delivering antibiotics in a locally applied and extended-release manner for patients receiving cranial replacement implants and bone grafting. This [...]

Dual Modal Gene Expression and Silencing Using Viral/Nonviral Chimeric Nanoparticles for Synergistic Gene Therapy

Cho S.K., Luu T., Wong S., Kwon Y.J., UC Irvine, US

Efficient, safe, and versatile gene delivery carriers that combine the viral vectors’ high gene delivery efficiency and the nonviral vectors’ high level of flexibility for structural and functional modifications were prepared. Adeno-associated virus (AAV) was [...]

Drug Delivery with Light-Activated Gold-Coated Liposomes

Orsinger G.V., Leung S.J., Knights S.S., Williams J.D., Romanowski M., University of Arizona, US

With the ultimate goal of delivering therapeutic compounds selectively to cancerous or diseased tissues and cells, we have presented liposome-based plasmon resonant nanocapsules. The described biocompatible composite delivery vehicle enables encapsulation and selective release of [...]

Electrically-Controlled Drug Release System to Assist Wound Healing

Zhu S., Mbugua J., Chase M., Maskrod J., Jung J.H., Nicholson III T., Fabrizio E., Mercado R., Crosslink, US

The localized, controlled delivery of therapeutic agents is an attractive prospect for drugs with detrimental systemic effects at large dosages. An electronically-controlled drug delivery system (DDS) for the controlled release of negatively charged model compounds [...]

Fabrication of Microelectrodes on Polyester Membranes for Dielectrophoretic Cell Capture

Hanke C., Dittrich P.S., Reyes D.R., National Institute of Standards and Technology, US

We present a new system for cell capturing on porous polyester (PET) membranes using dielectrophoretic forces. For the first time gold microelectrodes were fabricated on PET membranes using conventional photolithographic techniques. Their characterization revealed no [...]

Aerosol based fabrication of thiol-capped gold nanoparticles and their application for gene transfection

Byeon J.H., Roberts J.T., Purdue University, US

Thiol-capped Au nanoparticles can be used as sensitive probes of gas and vapor concentrations, as magnetic materials in data storage devices, for selective drug delivery, and for biomedical imaging.3 In this study, ambient-spark-produced-Au-nanoparticle-laden nitrogen gas [...]