US – Page 117 – TechConnect Briefs

Probing the Distribution of Gliadin in Dough and Baked Bread Using Conjugated Quantum Dots as a Labeling Tool

Ansari S., Kokini J., University of Illinois at Urbana-Champaign, US

Nowadays quantum dots (QDs) technology is most commonly used in medical application as a probe to diagnostic procedures and also for designing of biosensors. However, the application of this technology is very new in food [...]

Raman Imaging for Characterization of Novel Multi-Layer Solid Dosage Forms

Rzhevskii A., Thermo Fisher Scientific, US

Multi-layer tablets, combination drug formulations and other innovative dosage forms are getting increasing attention in pharmaceutical industry. As structure and composition of the multi-layer dosages become more complicated, the development and application of techniques for [...]

Influence of metallic, ceramic, and plastic MALDI surface materials on the ionization efficiency and quality of mass spectrometric data

Hieke A., Stanford University, School of Medicine, US

Imperfections of the MALDI ionization process of proteins and peptides impose considerable limitations on the utility of mass spectrometry in basic life sciences and ultimately on the application in biomarker discovery and medical diagnostics. Improved [...]

Continuous Flow Real-Time Pcr Platform for High Throughput Environmental Monitoring

Ray T., Hatch A., Lintecum K., Chao S-H, Youngbull C., Arizona State University, US

We present the design and development of a continuous flow quantitative Polymerase Chain Reaction system, suitable for multi-analyte, high-throughput, semi-autonomous assays. This system operates in a continuous fashion and is able to detect many different [...]

Nanofabrication Techniques for Fully Integrated Sensing Platforms

Mujeeb-U-Rahman M., Adalian D., Sencan M., Scherer A., California Institute of Technology, US

Designing small scale integrated systems for sensing and actuation has gained lots of interest in recent years. Currently, subsystems are fabricated separately and then bonded together to form an integrated platform. This poses a fundamental [...]

Magnetization of hydrogel particles: a novel urine tuberculosis antigen test

Paris L., Cox A., Petricoin E., Liotta L., Luchini A., George Mason University, US

This study aims at developing a nanotechnology-based screening test that would reliably detect early stage tuberculosis (TB) infection and discriminate active from latent infections. The use of urine in TB testing has been hampered by [...]

Performance Comparison of Immunosensors Modified with Polymers, Nanoparticles and Antibody

Leung S.W., Lai J.C.K., Assan D., Idaho State University, US

Our research group is in the quest of developing a biosensor platform that is fast in response time, versatile that can be used to detect a variety of chemicals species and metabolites, and ultra-sensitive that [...]

Ultra-High Performance Immunosensor Prepared by Glassy Carbon Electrode Modified with Nano Gold Particles and Antibody

Assan D., Mozneb M., Lai J.C.K., Leung S.W., Idaho State University, US

In previous reports, we have successfully fabricated biosensors that could measure chemical species that are important in environmental monitoring, as well as metabolites that are indicators of the proper functioning of our body. In our [...]

AFM resolves dynamic effects of ethambutol on nanomechanics and nanostructures of single dividing mycobacterium cells

Wu Y., Sims R.C., Zhou A., Utah State University, US

Dynamic nanomechanics and nanostructures of dividing and anti-mycobacterial drug treated mycobacterium are yet to fully elucidate. Atomic force microscopy (AFM) is a promising nanotechnology to characterize such dynamic properties, especially at the single cell level. [...]

Amplified On-Chip Fluorescent and Colorimetric Detection of DNA and RNA Hybridization by Surface-Initiated Enzymatic Polymerization

Tjong V., Yu H., Hucknall A., Chilkoti A., Duke University, US

We present a new on-chip, isothermal signal amplification technique for direct detection of unmodified DNA and RNA on microarrays using terminal deoxynucleotidyl transferase (TdT), a template-independent DNA polymerase that catalyzes the sequential addition of deoxynucleotides [...]