Materials for Drug & Gene Delivery

Electrically-Controlled Drug Release System to Assist Wound Healing

Zhu S., Mbugua J., Chase M., Maskrod J., Jung J.H., Nicholson III T., Fabrizio E., Mercado R., Crosslink, US

The localized, controlled delivery of therapeutic agents is an attractive prospect for drugs with detrimental systemic effects at large dosages. An electronically-controlled drug delivery system (DDS) for the controlled release of negatively charged model compounds [...]

Triple protection delivery system for retinaldehyde: Preparation, skin penetration and controlled release at the hair follicles

Supmuang P., Wanichwecharungruang S., Chulalongkorn University, TH

Vitamin A and its derivatives including retinaldehyde possess serious instability problem. To continuously supply skin with un-degraded retinaldehyde, nanoparticles which could penetrate into skin via hair follicles and then slowly release this vitamin A derivative [...]

Drug Delivery with Light-Activated Gold-Coated Liposomes

Orsinger G.V., Leung S.J., Knights S.S., Williams J.D., Romanowski M., University of Arizona, US

With the ultimate goal of delivering therapeutic compounds selectively to cancerous or diseased tissues and cells, we have presented liposome-based plasmon resonant nanocapsules. The described biocompatible composite delivery vehicle enables encapsulation and selective release of [...]

A Novel Single Step Method of Synthesizing Large Unilamellar Liposomes for Biomedical Applications

Phapal S.M., Sunthar P., Indian Institute of Technology - Bombay, IN

We have investigated various coacervation techniques for liposome synthesis. The aim is to study various local mixing conditions and their effect on the size of liposomes formed. To control the extent of mixing, four different [...]

Dual Modal Gene Expression and Silencing Using Viral/Nonviral Chimeric Nanoparticles for Synergistic Gene Therapy

Cho S.K., Luu T., Wong S., Kwon Y.J., UC Irvine, US

Efficient, safe, and versatile gene delivery carriers that combine the viral vectors’ high gene delivery efficiency and the nonviral vectors’ high level of flexibility for structural and functional modifications were prepared. Adeno-associated virus (AAV) was [...]

Surface Functionalized Multicomponent Envelope Type Nanosystems for Improved Gene Delivery

Pozzi D., Orlando V., Augusti Tocco G., Biagioni S., Cardarelli F., Bifone A., Caraccioloa G., Sapienza University of Rome, IT

Recently, a new programmed packaging strategy in which various “soft devices” that control intracellular trafficking are incorporated into single nanoparticles has been proposed. Here we apply such a novel concept to develop multicomponent envelope-type nanosystems [...]

Controlled- Release Antibiotic Nanoparticles for Cranial Transplantation and Bone Grafting

Adusumilli A.N., Dammalapati S., Fu P.K.-L., Governors State University, US

The objective of this research is to develop a unique nanoparticulate system that is capable of delivering antibiotics in a locally applied and extended-release manner for patients receiving cranial replacement implants and bone grafting. This [...]

Sequential Surface Functionalization by Polyoxometalates and Lysine Renders Non-toxic Gold Nanoparticles Strong Antibacterial Agents

Daima H.K., Selvakannan P.R., Bhargava S.K., Bansal V., RMIT University, AU

Gold nanoparticles (AuNPs)are considered as biocompatible and important component for biomedical applications. In current study, AuNPs were synthesised using tyrosine amino acid mediated reduction of gold ions. These nanoparticles were functionalised with two polyoxometalates (POMs) [...]

Development of PHEMA-Chitosan nanospheres and encapsulation of RSV-F DNA vaccine

Eroglu E., Waffo A.B., Dennis V.A., Singh S.R., Alabama State University, US

Respiratory Syncytial Virus (RSV) causes serious lower respiratory tract diseases among infants. Unfortunately, no effective vaccine to prevent RSV infection has been developed. RSV fusion gene (RSV-F) is conserved among various strains of RSV. Therefore, [...]

Surfactant Effect on Intercellular Transport of DNA, Proteins, and Electrolytes

Assan D., Gao X., Lai J.C.K., Leung S.W., Idaho State U, US

Surfactants play a key role on bodily functions at molecular level, such as cell signaling and signal transmission. Their importance in cell survival is well recognized, but the surfactant effect on intermolecular/interfacial mass transport is [...]

Electrospun Nanofibrous Scaffold for Controll Drug Delivery

Leung V., Hartwell R., Faure E., Yang H., Ghahary A., Ko F., University of British Columbia, CA

This study aims to design methods for controlling drug release from polymer nanofibres, and use these methods as a guide for designing nanofibre wound dressings with customizable release profile for a range of drugs. The [...]

Designing Responsive Materials with Chemically Amplified Sensitivity to NIR light

Fomina N., McFearin C., Sermsakdi M., Morachis J., Almutairi A., University of California at San Diego, US

We employ near infrared (NIR) light as an external trigger for controlled material degradation and targeted release of a payload. NIR light can penetrate through tissues to an appreciable depth without scattering or damaging it. [...]

Nanostructured cellulose materials: adsorption of antibiotics onto cellulose fibers functionalized with glycidylmethacrylate for the manufacturing of antibacterial fabrics

Vismara E., Torri G., Valerio A., Graziani G., Montanelli A., Melone L., Politecnico di Milano, IT

Abstract: In this work we report how cotton fibers can be easily functionalized with glycidylmethacrylate (GMA) by means of the Fenton’s reaction and used for the manufacturing of biomedical textiles having significant capability to adsorb [...]

Self Assembled Nanostructures of Triblock Co-polymer and Plasmid DNA for Gene Delivery

Daima H.K., Shankar P.R. Selvakannan S., Bhargava S.K., Bansal V., RMIT University, AU

In present work, we have used tri-block copolymer (PEO-PPO-PEO) as a non-viral vector to deliver plasmid DNA (pDNA). Green fluorescence protein (GFP) plasmid DNA was used as a model plasmid DNA. Addition of pDNA to [...]

Supramolecular assemblies of cisplatin and polyelectrolytes: preparation, characterization and activity against cancer cells

Vieira D.B., Kim V., Petri D.F.S., Menck C.F.M., Carmona-Ribeiro A.M., Universidade de Sao Paulo, BR

Nanoformulation of cisplatin (Cis) is important to circumvent its high toxicity against normal cells. In this work, Cis cationic nanoparticles were prepared by the self-assembly of drug and oppositely charged polyelectrolytes (carboxymethylcellulose, CMC; chitosan, CH; [...]

Orally Delivered Polymeric nanoparticles of Lopinavir: Development and Statistical optimization, in vitro and ex vivo studies

Joshi G., Sawant K.K., M S University of Baroda, IN

Nanoparticles (NPs) have been extensively studied for oral drug delivery. NPs are taken up intact by M cells of peyer’s patches of gut associated lymphoid tissue (GALT) followed by its systemic circulation thereby preventing first [...]

In vitro anticancer activity of poly(3-hydroxybutyrate) nanoparticles loaded with antitumor drug Paclitaxel

Yakovlev S.G., Bonartsev A.P., Bonartseva G.A., Bagrov D.V., Efremov Yu.M., Boskhomdzhiev A.P., Filatova E.V., Ivanov P.V., Makhina T.K., Bonartseva G.A., A.N.Bach’s Institute of Biochemistry Russian Academy of Sciences, RU

We have produced nanoparticles loaded with antitumor drug paclitaxel. Operated nanospheres were prepared on the base of a biodegradable and biocompatible polymer of bacterial origin, poly(3-hydroxybutyrate) (PHB). PHB nanoparticles with paclitaxel (230±55 nm in diameter) [...]

Encapsulation and Characterization of BSA in PLA-PEG Nanoparticles as a Model for Chlamydia trachomatis rMOMP-278 Protein Nanovaccine Delivery System

Taha M., Singh S.R., Moore C., Agee R., Dennis V.A., Alabama State University, US

Chlamydia trachomatis is a major human health pathogen because it is the most reported sexually transmitted disease. There is no effective mucosal vaccine against Chlamydia. One of the major problems of the C.trachomatis vaccine development [...]

Papers: