We have recently introduced a new microcantilever transduction mechanism that is designed to scale to large arrays on a single chip while maintaining a very compact form factor and high sensitivity. It is based on [...]
We propose a novel scheme for the en masse fabrication and selective functionalization of field effect silicon nanoplate devices to enable the ultrasensitive, simultaneous and label-free detection of multiple biomolecular species in real time. The [...]
We have fabricated label-free protein biosensors based on aptamer-modified carbon nanotube field-effect transistors (CNTFET) for detection of immunoglobulin E (IgE). Since aptamers are artificial oligonucleotides, the aptamers are smaller in size than the Debye length. [...]
, Hecke S.
, Kaczor M.
, Linke S.
, Lohmüller T.
, Motz M.
, Müller U.
, Neugebauer S.
, Nisch W.
, Schuhmann W.
, Sorsa J.
, Spatz J.
, Stelzle M.
, NMI Natural and Medical Sciences Institute, DE
The primary objective of this research is to create electrode systems for use as electrochemical transducers with enhanced sensitivity in order to enable detection of low concentration diagnostic targets not accessible to date. NanoBioPore sensors [...]
The possibility to investigate single cell metabolic activity in real time in sub-nanoliter volume could expand our knowledge of cellular physiological processes. Extracellular pH is a critical parameter for many cellular processes and extracellular acidification [...]
We are proposing an all-electrical approach to mechanical cell diagnostics that uses a combination of electromanipulation for stimulus and capacitance for sensing. We have successfully used the capacitive sensor to detect the electrical trapping (using [...]
This implantable biomarker sensor combines nanoscale magnetic relaxation switches (MRSW) and the versatility of microfabricated structures tp be read by MRI. MRSW are magnetic iron oxide nanoparticles that can be functionalized to detect a variety [...]
We present a new method to count cells on a microelectonic lab-on-a-chip integrating an array of Dielectrophoretic (DEP) cages and embedded optical sensors. Cells are trapped by DEP cages above photodiodes measuring the optical near [...]
, Borgen E.
, Drese K.S.
, Hauch S.
, Laureyn W.
, Liu C.
, Llaudet E.
, Nilsson O.
, Nygren A.O.H.
, O’Sullivan C.K.
, Ritzi M.
, Roeser T.
, IMEC, BE
A consortium of 7 European partners has undertaken the challenging task to develop a microfluidic system (μTAS) capable of the isolation/enrichment and consecutive RNA/DNA characterization of circulating tumor cells (CTCs), to be used as a [...]
The lysing of human blood leukocyte cells prior to performing e.g. DNA analysis is performed on a routine basis in most biochemical labs. Well-established techniques include using a lysis agent or using mechanical methods such [...]
Many diagnostic or analytical tasks are based on detection of specific amplificates of DNA or RNA. Lab-on-Chip systems are developed for such tests because often only small sample volumes and analyte concentrations are available. A [...]
Journal: TechConnect Briefs
Volume: 2, Technical Proceedings of the 2007 NSTI Nanotechnology Conference and Trade Show, Volume 2
Published: May 20, 2007
Industry sector: Medical & Biotech
Topic: Diagnostics & Bioimaging