Bio Micro Sensors and Systems

Modeling of the Dielectrophoretic Forces Acting upon Biological Cells: A Numerical Comparison between Finite Element/Boundary Element Maxwell Stress Tensor Methods and Dipole Point Approach

Benselama A., Pham P., Canot É., CEA, FR

Maxwell Stress Tensor (MST) method is investigated in this study to quantify the degree of approximation made with the point dipole method in respect to dielectrophoresis (DEP) in microdevices. Latex particles and biological cells immersed [...]

An Approach for Fabrication of Polymer-based Bio-analytical Microfluidic Devices

Wang M., Weng K-Y, Huang C-C, Liu W-P, Yao L-Y, Industrial Technology Research Institute, TW

Polymer is well suited as a substrate for bio-application devices due to its high dielectric constant, bio-compatible, low cost and ease of microfabrication. The primary goal is the successful fabrication of microchannels for biochip commonly [...]

A Generic Sensor for Ultra Low Analyte Concentration Detection

Hedley J., McNeil C.J., Burdess J.S., Harris A.J., Dobson M.G., Suarez G., Berney H., Newcastle University, UK

This paper reports on the development of a MEMS based generic mass sensor system (international patents pending) aimed at quantitative analyte measurement with a sensitivity of the order of 0.01 ng per cm sq. The [...]

Characterization of Micropumps for Biomedical Applications

Haik Y., Hendrix J., Kilani M., Galambus P., Chen C-J., Florida State University, US

A novel class of micro pump was developed at the Biomagnetic Engineering Lab at Florida State University. The pump operates by utilizing the viscous effects that are dominant the micro scale and by spinning a [...]

Modeling of Dielectrophoresis for Handling Bioparticles in Microdevices

Yao G.F., Flow Science Inc., US

Dielectrophoresis can be used to trap and position bioparticles efficiently and sucessfully in BioMEMS devices. This paper present a computational model to simulate this process. In particular, the model will solve for electric potential distribution, [...]

Quadruptlets-Microneedle Array for Blood Extraction

Khumpuang S., Kawaguchi G., Sugiyama S., Ritsumeikan University, JP

A novel fabrication of PMM(Polymethylmethacrylate) microneedle array using synchrotron radiation deep X-ray lithography is presented in this work. In general, microneedles with holes are required for biomedical application. The crown-shaped structure with quadruplets-microneedle is an [...]

A Disposable Glucose Biosensor Based on Diffusional Mediator Dispersed in Nanoparticulate Membrane on Screen-Printed Carbon Electrode

Gao Z., Xie F., Shariff M., Arshad M., Ying J.Y., Institute of Bioengineering and Nanotechnology, SG

In this paper, we described a disposable glucose biosensor based on co-dispersion of a diffusional polymeric mediator and glucose oxidase (GOX) in nanoparticulate membrane on screen-printed carbon electrode. The biosensor exhibited classical features of a [...]

A Microfluidic System with Nonenzymatic Glucose Sensor

Joo S., Park S., Lim H., Chung T.D., Kim H-C, Seoul National University, KR

In this paper, we report an amperometric-type enzymeless glucose sensor system based on nanoporous platinum (Pt) and platinum/platinum oxide (Pt/PtO) reference electrode, which are integrated with microfluidic chip. Glucose sensor employing no enzyme implies a [...]

Glucometers to Detect for Heart Attack

Haik Y., Qablan A., Zwolinski A., Chen C-J., Florida State University, US

Acute Myocardial Infarction (AMI), commonly referred to as a heart attack, is a disorder in which damage to an area of heart muscle occurs because of an inadequate supply of oxygen to that area leading [...]

Optical Detection of Integrin AvB3 Using a Nanostructured Lipid Bilayer Membrane Biosensor

Worsfold O., Nishiya T., Fujirebio Inc., JP

An ultra-sensitive optical bionanosensor platform for integrin avb3 loaded human umbilical vein endothelial cells (HUVECs) was fabricated. The bionanosensor design involved the incorporation of an RGD (arginine-glycineaspartate) containing peptide conjugated BODIPY lipid soluble dye (donor) [...]

Micro-Patterning of Ionic Reservoirs within a Double Bilayer Lipid Membrane to Fabricate a 2D Array of Ion-Channel Switch Based Electrochemical Biosensors

Sansiñena J.M., Yee C.K., Sapuri A., Swanson B.I., Redondo A., Parikh A.N., Los Alamos National Laboratory, US

We present a simple approach for the design of ionic reservoir arrays within a double phospholipid bilayer to ultimately develop a 2D array of ion-channel switch based electrochemical biosensors. As a first step, a primary [...]

Potentiometric Biosensors Based on Silicon and Porous Silicon

Basu I., Subramanian R.V., Mathew A., Chadha A., Bhattacharya E., Indian Institute of Technology Madras, IN

Detection and estimation of Triglycerides and Urea are clinically important. We report fabrication of potentiometric biosensors based on silicon and porous silicon and estimation of triglycerides and urea based on enzymatic reactions. The sensor is [...]

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