A novel fabrication of PMM(Polymethylmethacrylate) microneedle array using synchrotron radiation deep X-ray lithography is presented in this work. In general, microneedles with holes are required for biomedical application. The crown-shaped structure with quadruplets-microneedle is an alternative design for handling blood without the fabrication of holes. The previous work reported the fabrication method of single-tip microneedle with a nano-scale tip size. Currently, we applied similar method to approach the sharp tips on the new design for blood extraction purpose. The microneedles were fabricated by exposing X-ray to PMMA sheet with a novel technique so called PCT(Plain-pattern to Cross-section Technique). The density is 1024 needles/cm2 and the dimension of X-ray mask pattern has been optimized from several designs. A microneedle test on chicken skin shows a tiny size of skin flaring after the penetration. By the capillary force, blood can be extracted and kept after flowing into the grooves. The grooves enhance the area of storing blood after the insertion of the microneedle to skin. The microneedle has also been being simulated by a finite element software for flow analysis.
Journal: TechConnect Briefs
Volume: 1, Technical Proceedings of the 2004 NSTI Nanotechnology Conference and Trade Show, Volume 1
Published: March 7, 2004
Pages: 205 - 208
Industry sectors: Medical & Biotech | Sensors, MEMS, Electronics
Topicss: Biomaterials, Chemical, Physical & Bio-Sensors