Acute Myocardial Infarction (AMI), commonly referred to as a heart attack, is a disorder in which damage to an area of heart muscle occurs because of an inadequate supply of oxygen to that area leading to damage or death of cells. The damaged tissue results in a permanent loss of contraction of this portion of the heart muscle. AMI occurs in approximately 2 out of 1,000 people per year. It is a major cause of sudden death in adults. Currently there is an interest for the earliest possible determination of AMI for patients admitted to the emergency room with chest pains, both to determine which patients can be safely sent home and which need further care, and because for those how suffered an AMI, treatment with thrombolytic therapy is most beneficial the earlier after an AMI the treatment is instituted. This paper presents a point of care device for detection of AMI using a magnetic immunoassay. The magnetic immunoassay utilizes a standard solid-phase enzyme linked immunoassay (ELISA). On one side a glucose molecule is attached to an antibody that is linked to a cardiac marker and on the other side of the cardiac marker is an antibody that is linked to a nanomagnetic particle. The point of care device presented in this paper for detection of AMI is a glucometer.
Journal: TechConnect Briefs
Volume: 1, Technical Proceedings of the 2004 NSTI Nanotechnology Conference and Trade Show, Volume 1
Published: March 7, 2004
Pages: 215 - 216
Industry sectors: Medical & Biotech | Sensors, MEMS, Electronics
Topics: Biomaterials, Chemical, Physical & Bio-Sensors