Cancer Diagnostics, Imaging & Treatment

Nanomedicine: Engineering of a Tri-Imageable Nanoparticle for Cancer Diagnostics

Bumb A., Dobson PJ., Fugger L., Choyke P., Brechbiel MW., National Cancer Institute/University of Oxford, US

We have created a potential targeted drug delivery platform with three imaging reporters by coupling the magnetic properties of USPIOs with near infrared fluorescence of Cy5.5 and gamma emissions of Indium-111 that is chelated to [...]

Gold Nano-Probes as Targeted CT Contrast Agents for In-vivo cancer Imaging

Popovtzer A., Popovtzer R., Agrawal A., Shlomi M., Popovtzer A., Popovtzer R., Balter J., Carey T.E., Kopelman R., University of Michigan, US

This research describes a new class of immuno-targeted and cancer specific CT contrast agents, which enable CT imaging of cancer at cellular and molecular resolution. The method is based on the development of gold nano-probes [...]

Strategies for enhanced brain tumor accumulation of magnetic nanoparticles for potential drug delivery

Chertok B., David A.E., Yang V.C., University of Michigan, US

The purpose of this study was to elucidate strategies to enhance magnetically mediated accumulation of iron-oxide-based nanoparticles in brain tumors for potential localized delivery of chemotherapeutic agents. In particular, we evaluated administration of the nanoparticles [...]

5-aminolevulinic Acid Conjugated Gold Nanoparticles for Cancer Treatment

Khaing Oo M.K., Yang X., Wang H., Du H., Stevens Institute of Technology, US

To improve 5- aminolevulinic acid’s (5-ALA) selective retention in tumor cells and efficient damage tumor cells in photodynamic therapy (PDT), biocompatible gold (Au) nanoparticles were proposed as the carrier to selectively deliver 5-ALA into tumor-like [...]

Multiwalled Carbon Nanotube-Doxorubicin Supramolecular Complexes for Cancer Therapeutics

Ali-Boucetta H., Al-Jamal K.T., Kostarelos K., The School of Pharmacy, University of London, UK

The field of drug delivery is being revolutionised by the discovery of novel nanomaterials such as carbon nanotubes (CNTs) capable of traversing the plasma membrane and promoting the cellular uptake of small molecules and macromolecules [...]

Genomics and Proteomics: Information-Theoretic Analysis in Frequency Domain

Lyshevski S.E., Krueger F., Rochester Institute of Technology, US

We perform the frequency-domain analysis to examine large-scale genomic and proteomics data. This ensures qualitative and quantitative coherency.

Colorectal Cancer Cell Detection by Chitosan Nanoparticle Conjugated with Folic Acid

Yang S.J., Chen J-W, Shieh M.J., Institute of Biomedical Engineering, TW

Endoscopy is a common diagnosis device for the detection of colorectal cancer and there are two methods to improve the diagnostic sensitivity. One is chromoendoscopy, and the other is magnifying endoscopy. Color contrast dye, such [...]

Chitosan Nanoparticle Combined with Ultrasound for Cervical Cancer Detection

Tsai K-C, Shieh M.J., Yang S.J., Lin W-L, Chen W-S, Institute of Biomedical Engineering, TW

Photodynamic medicine is a novel approach for cancer detection and treatment via different photosensitizers and suitable light source. The 5-Aminolevulinic acid (5-ALA) can be converted into protoporphyrin IX (PpIX) that can be utilized as a [...]

Biochip-Based Test System for Cancer Diagnostics. Simultaneous Quantitation of Total and Free Forms of Prostate-Specific Antigen

Osipova T., Sokolova Z., Ryabykh T., Karaseva V., Modorsky M., Matveev V., Baryshnikov A., N.N. Blokhin Cancer Research Center, RAMS, RU

Background. Prostate-specific antigen (PSA) is the most useful marker for the early detection of prostate cancer (PCa). The use of two PSA forms – total (PSAt) and free (PSAf) makes it possible to differentiate benign [...]

Specific device for cells sampling

Cosnier M.L., Martin F., Ratel D., Berger F., Caillat P., Commissariat à l’Energie Atomique, FR

We developed a miniaturized biopsy tool for harvesting molecules of interest in delicate areas such as brain. This tool permits harvesting of intact cells permitting genomic analysis on these cells. The sampling tool is manufactured [...]

New efficient nanostructural near-IR photosensitizer for photodynamic therapy of malignancies based on micellar dispersion of zinc octa-4,5-decylthio-3,6-chloro-phthalocyanine

Meerovich G.A., Meerovich I.G., Meerovich G.A., Meerovich I.G., Lukyanets E.A., Negrimovsky V.M., Barkanova S.V., Zorin A.A., Umnova L.V., Oborotova N.A., Loschenov V.B., Vorozhtsov G.N., Baryshnikov A.Yu., N.N.Blokhin Russian Cancer Research Center of RAMS, RU

The work is devoted to investigation of new nanostructural photosensitizer on a base of zinc octa-4,5-decylthio-3,6-chloro-phthalocyanine solubilized in micellar dispersion. Photosensitizer possesses its absorption maximum at about 730 nm and can be considered promising for [...]

Influence of liposome size on accumulation in tumor and therapeutic efficiency of liposomal near-IR photosensitizer for PDT based on aluminum hydroxide tetra-3-phenylthiophthalocyanine

Meerovich G.A., Meerovich I.G., Meerovich G.A., Meerovich I.G., Pevgov V.G., Lukyanets E.A., Oborotova N.A., Gurevich D.G., Zorin A.A., Derkacheva V.M., Smirnova Z.S., Loschenov V.B., Vorozhtsov G.N., Baryshnikov A.Yu., A.M. Prokhorov General Physics Institute of RAS, RU

Size of nanoparticles is considered to be the one of main factors determining the efficiency of nanostructural antitumor drugs. Current work was performed to estimate the influence of liposomal size distribution on level and selectivity [...]

Mathematical Model of effect of drug delivery on blood flow in external magnetic field by Magnetic Nanoparticles

Mishra S., Katiyar V.K., Arora V., Indian Institute of Technology, Roorkee, IN

Magnetism is one of the major contributors in biological and biomedical research. Efficient drug targeting is vital for the medical treatment of various diseases. In magnetically targeted therapy, a cytotoxic drug is attached to a [...]

Multifunctional siRNA Delivery System for Cancer Therapy

Taratula O., Salva R., Pandya I., Wang A., Minko T., He H., Rutgers-Newark University, US

The main obstacle to siRNA therapy is in delivering RNA across the cell membrane. Furthermore, new methods for monitoring therapeutic responses are highly desirable. Here we report the development of a multifunctional nanomedicine platform for [...]

Preparation and investigation of biological activity of thermosensitive liposomes loaded with doxorubicin

Tazina E.V., Polozkova A.V., Orlova O.L., Ignatieva E.V., Mescherikova V.V., Wainson A., Yarmonenko S.P., Oborotova N.A., N.N.Blokhin Russian Cancer Research Center of RAMS, RU

Purpose: Preparation of thermoliposomes with doxorubicin and investigation of their effect on solid Ehrlich carcinoma and B-16 mouse melanoma in combination with hyperthermia. Materials and methods: Thermosensitive liposomes were prepared using DPPC, DSPC, DSPE-PEG 2000 [...]

Multi- Walled Carbon Nanotubes Increase the Efficiency of Hyperthermic Chemotherapy

Levi-Polyachenko N.H., Merkel E., Jones B.T., Wagner W.D., Carroll D.L., Stewart IV J.H., Wake Forest University Health Sciences, US

A clinically applied method to enhance drug localization for abdominal malignancies of colorectal cancer involves a two-hour perfusion of hyperthermic (40-42ºC) chemotherapeutic agents; however, all cavity tissues are subjected to enhanced drug delivery due to [...]

Bacterial Drug Delivery Systems and nanoparticles

Sharma R., Haik Y., UNCG, US

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Pharmacokinetic study of PEGylated plasmon resonant gold nanoparticles in tumor-bearing mice

Kogan B.Ya., Andronova N.V., Khlebtsov B.N., Khlebtsov N.G., Khlebtsov B.N., Khlebtsov N.G., Rudoy V.M., Dement’eva O.V., Sedykh E.M., Bannykh L.N., FGUP “GNC “NIOPIK”, RU

Gold nanorods and gold nanoshells have been synthesized. Nanorods have length of 50 nm, diameter of 15-20 nm. Nanoshells have 80 nm silica core diameter with 25 nm thick gold shells. Then poly(ethylene glycol) molecules [...]

Upconverting nanoparticles for photodynamic therapy

Chatterjee D.K., Zhang Y., National University of Singapore, SG

Photodynamic therapy involves killing of diseased cells by excitation of photosensitizer chemicals with high energy light to produce cytotoxic oxygen species from surrounding dissolved oxygen. However, poor tissue penetration of high energy light and hydrophobic [...]

Spatio-temporal Tumor Model for Analysis and Mechanism of action of Intracellular Drug Accumulation

Mishra S., Katiyar V.K., Arora V., Haridwar, IN

We have developed a one-dimensional tumor simulator to describe the biodistribution of chemotherapeutic drugs to a tumoral lesion and the tumor cell’s response to therapy. A three-compartment model is used for drug dynamics within the [...]

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