Pharmacokinetic study of PEGylated plasmon resonant gold nanoparticles in tumor-bearing mice

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Gold nanorods and gold nanoshells have been synthesized. Nanorods have length of 50 nm, diameter of 15-20 nm. Nanoshells have 80 nm silica core diameter with 25 nm thick gold shells. Then poly(ethylene glycol) molecules have been attached (using thiol groups) to surface of nanoparticles to provide their defense from reticuloendothelial system. BDF1 male mice bearing Lewis lung carcinoma were used. Aqueous suspensions of nanoparticles were inje ted in tail vein on the 7th day after tumor transplantation. Mice were decapitated through various time intervals after injection, and samples of blood, liver, tumour and muscles have been taken. Concentration of gold in samples was determined by atomic absorption spectroscopy method. Each value is average result of measurements for three mice. Very good effect of “enhanced permeability and retention” (EPR) is in case of PEGylated nanorods that collect in tumor even better than in liver and much more than in muscles. Such high accumulation contrast (35:1) can be applied for optical diagnostics of tumors and for targeted drug delivery without use of specific antibodies. Good but some lesser contrast (9:1) is in case of PEGylated nanoshells. Probably this is due to their larger sizes.

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Journal: TechConnect Briefs
Volume: 2, Nanotechnology 2008: Life Sciences, Medicine & Bio Materials – Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, Volume 2
Published: June 1, 2008
Pages: 65 - 68
Industry sector: Medical & Biotech
Topics: Biomaterials, Cancer Nanotechnology
ISBN: 978-1-4200-8504-4