Papers – Page 67 – TechConnect Briefs

Transient Analysis of Cooling of Biological Tissues Using Semi-Infinite Approximation

Jain A., Rensselaer Polytechnic Institute, US

In the present paper, we have presented an analytical approach for transient analysis of cooling of biological tissues due to blood flow. Semi-infinite approximation for tissues is used and continuum approach is used for modeling.

TMAZ Nanoparticles as Potential Drugs Influencing the Cellular Signal Transduction Pathways

Ivkovic S., Baranek T., Bendzko P., Schulz J., Klinomed Institut für Angewandte Nanotechnologie und Nanomedizin GmbH, DE

Currently, various antioxidants are under clinical investigation as an adjunct to standard and experimental cancer therapies. Anti-cancer activity of antioxidants may not only be attributed to their radical scavenger properties, but also to direct modulation [...]

Nanomagnetic Immunoassay for Rapid Detection of Escherichia coli

Haik Y., Qablan A., Chen C-J., Center for Nanomagnetics and Biotechnology, US

This study identifies a simple process to quickly conduct an analysis, under field conditions, for detection of pathogens. A magnetic sandwich immunoassay is developed for rapid isolation and detection of targeted pathogen. Escherichia coli BL21 [...]

Cellular Response to Nanoparticle Exposure

Erdos G.W., Moraga D., Palazuelos M., Powers K., University of Florida, US

Cells exposed to particles will phagocytose them and shuttle the endosomes to lysosomal compartments. Lysosomal mebranes rupture, possibly due to free radical formation. Proteases are released which inturn compromise the mitochondrial membranes. The mitochondria leak [...]

Intracellular Uptake of Folate Receptor Targeted Superparamagnetic Nanoparticles for Enhanced Tumor Detection by MRI

Sun C., Veiseh O., Kohler N., Gunn J., Lee D., Sze R., Hallahan A., Zhang M., University of Washington, US

Tumor specific superparamagnetic nanoparticle conjugates are currently being developed as targeting-contrast agents for magnetic resonance imaging (MRI). The application of such “smart” molecular imaging probes will have a significant clinical impact as a non-invasive method [...]

Apoptosis Characterization by Flouro-deoxy Glucose and Intracellular Sodium Distribution Using MicroPET/MRI in PC3 Induced Prostate Cancer in Mice Tumor

Sharma R., Kline R.P., Katz J.K., Columbia University, US

Background: Intracellular sodium (IC) and FDG accumulate in premalignant tumor sites. Hypothesis: High FDG and IC accumulation may characterize tumor stages. Objective: To develop rapid noninvasive hybrid microPET/MRI method to characterize PC3 tumor in mice. [...]

Imaging Bio-electro-mechanics with Scanning Probe Microscopy: Unveiling Nature’s Nanoscale Form and Function

Jesse S., Baddorf A.P., Rodriguez B.J., Gruverman A., Kalinin S.V., Oak Ridge National Laboratory, US

A novel scanning probe technique for studying the physiological structure and electro-mechanical properties of nanoscale biological systems is discussed. The almost universal presence of piezo response in biological material makes this method applicable to a [...]

Loss of Elasticity of Ageing Epithelial Cells, and Its Possible Reversal

Sokolov I., Woodworth C.D., Clarkson University, US

We investigated human epithelial cells of different age in-vitro by means of the atomic force microscopy. We found that older cells are considerably (~2-10 times) more rigid that younger cells. This helps to explain why [...]

Conical Tomograph: A Method for the Study of Macromolecular Assemblies

Zampighi G.A., Zampighi L., Fain N., Lanvazecchia S., Zampighi G.A., Zampighi L., University of California, Los Angeles School of Medicine, US

We have developed conical tomography to study the structure of macromolecular assemblies and organelles in their native cellular environment. Unlike the other related types of tomography, conical tomography has a higher throughput and more importantly, [...]

Combinatorial Selection of Cell-Specific Peptides by Phage Display Experiments

Veleva A.N., Patterson C., Cooper S.L., North Carolina State University, US

We report for the first time the selection of novel peptides that are highly specific for endothelial progenitor cells (EPC) by screening phage display libraries. Our strategy for isolation of ligand peptides for cell surface [...]