Papers – Page 66 – TechConnect Briefs

Structural Characterization of Novel Micro- And Nano-Scale Non-Viral DNA Delivery Systems for Cutaneous Gene Therapy

Foldvari M., Badea I., Wettig S., Verrall R., Bagonluri M., University of Saskatchewan, CA

Our main goal is to develop micro/nano-scale self-assembling delivery vehicles for cutaneous gene therapy. The objective of this study was to characterize the structural and physicochemical properties of novel dicationic lipid-based DNA complexes by atomic [...]

Nanoparticulate Drug Delivery Systems Based on Hydrotropic Polymers, Dendrimers, and Polymer Complexes

Park J.H., Park K., Huh K.M., Lee S-C, Lee W-K, Lee S-C, Lee W-K, Ooya T., Park J.H., Park K., Purdue University, US

Novel nanoparticulate drug delivery systems have received increasing attention for delivery of poorly water-soluble drugs and proteins. We have developed a new type of polymer micelles bearing the hydrotropic core segment, e.g., poly(2-(4-vinylbenzyloxy)-N,N-diethylnicotinamide), that enables [...]

Two-Dimensional Chemotherapy Simulations Demonstrate Fundamental Transport and Tumor Response Limitations Involving Nanoparticles

Sinek J., Frieboes H., Zheng X., Cristini V., University of California Irvine, US

Zheng et al. (2004) developed a multiscale, twodimensional tumor simulator with the capability of showing tumoral lesion progression through the stages of diffusion-limited dormancy, neo-vascularization (angiogenesis) and consequent rapid growth and tissue invasion. In this [...]

Formation of Nanoparticles of a Hydrophilic Drug using Supercritical CO2 and Microencapsulation for Sustained Drug Release

Thote A.J., Gupta R.B., Auburn University, US

The problem of initial burst release, in sustained drug delivery devices was resolved by reducing the active pharmaceutical ingredient particle size by using Supercritical Antisolvent technique with Enhanced Mass-transfer (SAS-EM)., Encapsulation was performed using a [...]

Peptidic Nanoparticles for Cancer Therapy and Diagnosis

Graff A., Tropel D., Raman SK., Machaidze G., Lustig A., Burkhard P., University of Basel, CH

Somatostatin peptides such as somatostatin 28 or 14 are known for their high binding affinity to G-coupled peptide receptors, which are often over-expressed on tumor cells. Using this binding property we developed a new type [...]

Liquid Crystal Interactions with Nanostructure and Applications to Diagnostics and Medical Research

Israel B.A., Murphy C.J., Abbott N.L., Platypus Technologies, US

We will present data demonstrating the use of liquid crystal detection of protein in the development of rapid, label free diagnostics and assays. We control the orientation of liquid crystals by the fabrication of surfaces [...]

Nanoelectronic CO2 Breath Sensors

Star A., Joshi V., Thomas D., Niemann J., Gabriel J.-C.P., Valcke C., Nanomix Inc, US

The measurement of carbon dioxide levels in respiration is a standard of care or guideline according to the American Heart Association, the American Association of Respiratory Care, and the American Society of Anesthesiologists, and is [...]

Plasma-Treated and Collagen-Coated PLLA Nanofiber Membrane for Cartilage Tissue Engineering

Chen J.P., Lee S.F., Chiang I.P., Chang Gung University, TW

Biodegradable nanofiber membranes from poly-L-lactic acid (PLLA) were prepared by electrospinning to be used as a scaffold in cartilage tissue engineering. Parameters during the electrospinning process were studied in detail in terms of diameters of [...]

Static Magnetic Field Effects on Cells: A Possible Road to Cell Differentiation

Prina-Mello A., Campbell V., Coey J.M.D., Trinity College, IE

The use of higher uniform magnetic field intensity, such as those used in magnetic resonance imaging, is thought to exert little influence at the cellular level. There are several experimental studies that indicate that magnetic [...]

Effect of Microtopography and Cell Concentration on T Lymphoid Cell Migration during in vitro Extravasation Process

Prina-Mello A., Volkov Y., Prendergast P.J., Trinity College, IE

The locomotion of leukocyte cells has been proved to be influenced by microtopographical patterns with and without surface chemistry [Prina-Mello et al., 2003, Lo et al., 2000]. In this study, parallel grooves were microfabricated on [...]