Papers – Page 69 – TechConnect Briefs

Maxitarg-A Novel Targeting Approach for Hepatic Cancer

Sonavane G.S., Devarajan P.V., Mumbai University Institute of Chemical Technology, IN

The efficacy of current cancer chemotherapy is mainly limited by toxicity associated with the systemic spread of anticancer drugs to normal tissues. Enhancing selectivity or maximizing targeting towards cancer cells would be important approach to [...]

Colloidal Gold Nanoparticles: A Versatile Platform for Developing Tumor Targeted Cancer Therapies

Paciotti G.F., Myer L., Kingston D.G.I., Ganesh T., Tamarkin L., CytImmune Sciences, Inc, US

CytImmune Sciences is developing colloidal gold nanoparticles (cAu) as a platform for tumor targeted drug delivery. Specifically two drugs are discussed: Aurimune-T and AuriTax. Aurimune-T is manufactured by covalently linking molecules of TNF and Thiol-derivatized [...]

The Use of Ligand Conjugated Superparamagnetic Iron Oxide Nanoparticles (SPION) for Early Detection of Metastases

Leuschner C., Kumar C., Urbina M.O., Zhou J., Soboyejo W., Hansel W., Hormes F., Pennington Biomedical Research Center, US

Breast cancer is the most common cause of cancer death in women; more than 75 % of patients die from skeletal metastases. The accurate diagnosis of metastatic disease is therefore crucial for treatment and survival. [...]

Circulating Tumor Cells: Capture with a Micromachined Device

Mohamed H., Murray M., Turner J.N., Caggana M., New York State Department of Health, US

The isolation and analysis of circulating tumor cells (CTCs) from blood is the subject of intense research. Tests to detect metastasis are available but progress is hampered by the lack of tumor-specific markers and predictable [...]