Papers – Page 65 – TechConnect Briefs

Enhanced Gene Delivery Efficiency in Resonant Acoustic Fields

Lee Y-H, Peng C-A, University of Southern California, US

Enhancement of DNA delivery efficiency has been improved by several physical and chemical approaches in the past decade. However, the application of those methods is hampered by large-scaled configurations. To augment gene delivery efficiency with [...]

Nano-structured Chitosan Self-Aggregates as a Drug Delivery Carrier

Bae M.S., Kwon I.C., Jeong S.Y., Lee K.Y., Hanyang University, KR

A number of novel delivery systems have been developed including the entrapment of drugs, proteins, antigens, or genes in small vesicles or within polymeric matrices. Colloidal delivery systems such as liposomes, microemulsions, and polymeric micelles [...]

Multi-scale Drug Release Modeling for Targeted Oral Drug Delivery (TODD)

Haddish B.N., Nyquist C., Haghighi K., Wu H.A., Corvalan C., Rickus J., Keshavarzian A., Purdue University, US

Conventional oral dosage forms deliver their active ingredient at rates that are high initially and decline afterward, showing a first order kinetics with the release determining step considered as the dissolution rate of the active [...]

New Highly Efficient Non-invasive Nanoparticulate Delivery Systems for the Treatment of Chronic Diseases

Sinner F.M., Institute of Medical Technologies and Health Management, Joanneum Research, AT

We herein report the overall goals of the joint project “Nano-Health” and preliminary results of two sub-projects (Nano-Health started in October 2004), which was positive evaluated by international reviewers within the first Call of the [...]

Superparamagnetic Iron Oxide Nanoparticles for Multiple Biomedical Applications

Hofmann H., Hofmann M., Petri-Fink A., Steitz B., von Rechenberg B., Hofmann H., Hofmann M., Juillerat J., Swiss Federal Institute of Technology Lausanne, CH

Superparamagneticiron oxide nanoparticles (SPION) were mixed at various ratios with different polymer solutions to obtain SPION coated with PVA modified by functional groups (amino-SPION, carboxy-SPION, and thiol-SPION). Studying human melanoma cells by theses different functionalized [...]

pH-Responsive Hydrogel with Controlled Swelling and Degradation Rate

Trujillo-Lemon M., Bowman C.N., Stansbury J.W., University of Colorado Denver and Health Sciences Center, US

Degradable polymeric materials that can be storage for months in aqueous enviroment before undergoing on-command controlled swelling and degradation were prepared and their kinetics of swelling and degradation were evaluated. The swelling and degradation rates [...]

Carbon Coated Magnetic Nanoparticles for Local Drug Delivery using Magnetic Implants

Fernández-Pacheco R., Ibarra M.R., Valdivia J.G., Marquina C., Serrate D., Romero M.S., Gutiérrez M., Arbiol J., Institute of Nanoscience of Aragon, ES

Bioferrofluid obtained using iron coated nanoparticles are promising candidates for magnetic drug delivery. The carbon cages made the particles biocompatibles and provide a suport for drug adsortion. We propose a new method in which gold [...]

Nano-Structured Vaccine Delivery

Yang Y-W, Wu C-A, National Taiwan University, TW

The nano-structured vaccine delivery systems, containing tomatine, n-octyl-b-D-glucopyranoside (OGP), phosphatidylethanolamine (PE), cholesterol, and ovalbumin, were examined in the present study by transmission electron microscopy. This adjuvant has been shown to elicit cytoxic T-lymphocyte (CTL) effect [...]

Polymeric Hybrid Microstructures for Smart Targeting and Drug Delivery

Dudia A., Kanger J.S., Subramaniam V., University of TWente, NL

Artificial cells (AC) refer to (sub) micro-vehicles that can perform a specific bio-function in the body, without being rejected from the immune system. Such smart targeting and drug delivery systems are aimed for use in [...]

Feasibility of Superparamagnetic Nanoparticles for Drug Delivery to the Inner Ear

Dormer K., Mamedova N., Kopke R., Liu J., Chen K., Gibson D., Jackson R., Costello M., Mondalek F., NanoBioMagnetics, Inc, US

An obstacle to effective treatment of inner ear diseases is the atraumatic delivery of therapeutics into inner ear perilymph. This study reports on the feasibility of using superparamagnetic nanoparticles as drug delivery vehicles.