Papers – Page 54 – TechConnect Briefs

Applications of Topology Optimization in the Design of Micro- and Nanofluidic Systems

Okkels F., Olesen L.H., Bruus H., Technical University of Denmark, DK

The material distribution method in topology optimization was developed in the late 1980ies for stiffness design of mechanical structures, and only recently the first steps have been taken towards implementing the method in fluidics. Topology [...]

Flat Fluidics: Programmable On-Chip Networks for Biological and Chemical Applications

Wixforth A., University of Augsburg and Advalytix AG, DE

We present a novel approach towards the needs of a versatile microfluidic chip-based microfluidic system with unique properties and functionality. Like for microarrays and in contrast to many existing microfluidic technologies, the fluid handling is [...]

Design Paradigms and Methodologies for Microfluidics

Hardt S., Darmstadt University of Technology, DE

This paper reviews and compares different strategies for designing and building up microfluidic systems, with a special emphasis on the system aspect as opposed to single components capable of performing only special operations. An overwhelming [...]

Bioinspired Miniaturization – Stretching Information from Coherence to Dissipation for Nano-to-Micro Integrated Intelligent Systems

Santoli S., International Nanobiological Testbed Ltd., IT

From previous results attained on the basis of thermodynamics, statistical physics and nanobiology it is shown that Artificial Intelligence (AI) concepts and their hard-wired implementations cannot satisfy the physical conditions for mimicking biological intelligence and [...]

Johnson-Kendall-Roberts Theory Applied to Living Cells

Chu Y-S, Dufour S., Thiery J.-P., Perez E., Pincet F., Laboratoire de Physique Statistique de l'ENS, FR

Cell adhesion is involved in a number of biological processes ranging from transport to the defenses of organisms. A quantitative understanding of the adhesion of cells is not often possible owing to their complexity in [...]

Ion Channel Simulations by the TR-PNP Model and the Excess Chemical Potential Approach

Hu S., Hess K., Beckman Institute, University of Illinois at Urbana-Champaign, US

We describe a new method referred to as TR-PNP model to study general types of nanostructure ion channels. Our method extends the common continuum methods to include particle like properties, such as the ion trapping [...]

Systems Biology Conceptual Modeling by Means of Discrete-event Simulation (DNA-RNA-Protein)

Yeol J.W., Barjis I., Barjis J., Barjis I., Barjis J., Berri S., Ryu Y., Polytechnic University, US

In this paper discrete-event simulation modeling technique is used to model and simulate biological processes. In particular, we study application of discrete-event simulation to model processes taking place in Glycolosis and capture dynamic behavior of [...]

A Multi-scale, Integrative Model of Cellular Electrophysiological Response Incorporating Intra/Extra-cellular Transport & Dynamics

Feng J.J., Krishnamoorthy S., Sundaram S., CFD Research Corporation, US

Spurred by the growing confluence of nano and bio technologies, several novel micro/nano platforms (see for example, whole cell patch clamp devices [1]) are emerging for the high-throughput and/or high-fidelity study of the electrophysiological response [...]

Application of Grid Focusing Methodology to Transport Monte Carlo Model for Ion Channel Simulations

Kathawala G.A., van der Straaten T., Ravaioli U., University of Illinois at Urbana-Champaign, US

Simulation of Ion Channels has long been an outstanding research problem in the biophysical community. Our transport Monte Carlo model BioMOCA is a particle based approach where we treat water implicitly. It has been used [...]

Interaction of Coupled Particles Based on Lennard-Jones and Spring Forces in Brownian Ratchet Devices

Retkute R., Gleeson J.P., University College Cork, IE

Electrophoresis is a technique used to separate polyelectrolyte strands of different lengths. One of its fields of application in nanotechnology is in the separation of DNA. Chains of particles can undergo net transport on a [...]