Papers – Page 53 – TechConnect Briefs

Electrokinetic and Hydrodynamic Focusing/Switching in Microfluidics

Yang R-J, Chang C-C, Huang S-B, Lee G-B, National Cheng Kung University, TW

This paper presents an investigation on hydrodynamic/electrokinetic focusing and switching, which are crucial for microfluidic applications. The hydrodynamic/electrokinetic focusing phenomenon is first theoretically modeled by employing a potential flow theory, and this simple theoretical model [...]

High Sensitivity, Microfluidic Immunoassays utilizing DNA-conjugated Antibodies to Accelerate the Electrophoretic Separation of Antigen-Antibody Complexes

Wada H.G., Kawabata T., Kazakova I., Simeonov A., Park C., Kechagia P., Spaid M., Watanabe M., Satomura S., Wako Pure Chemical Industries Ltd., US

The promise of microfluidic immunoassays in microchips has been the miniaturization, integration and automation of rapid immunoassays. The typical microfluidic assays have used fluorescent dye labeled antibodies in direct binding assays or labeled antigens in [...]

Electrokinetic Instabilities and Sample Stacking

Lin H., Oddy M.H., Santiago J.G., Stanford University, US

Microfabrication technology has enabled the application of electrokinetics as a method of performing chemical analyses and achieving liquid pumping in electronically-controlled microchip systems with no moving parts. This talk reviews progress at Stanford in the [...]

Multiscale Computation of Fluid and Ion Transport in Nanochannels: The Effect of Partial Charges

Joseph S., Chatterjee A.N., Aluru N.R., Beckman Institute of Advanced Science and Technology, US

We demonstrate a hierarchical multiscale methodology to solve ion transport in nanoscale channels and show that the partial charges from quantum calculations significantly alter transport properties and I-V plots for electrolytes in confined geometries. Effects [...]

Understanding the Cytoplasmic Transport of Synthetic Gene Vectors

Pangarkar C., Dinh A.T., Mitragotri S., university of california, santa barbara, US

We use fluorescence video microscopy and single particle tracking to elucidate some of the fundamental mechanisms involved in intracellular trafficking of non-viral gene vectors. Transport of polymer-DNA complex, which are internalized via endocytosis, is almost [...]

Characterization of a Solid State DNA Nanopore Sequencer using Multi-Scale (Nano-to-Device) Modeling

Jenkins J.W., Sengupta D., Sundaram S., CFD Research Corporation, US

The rapid convergence of nanotechnology and biotechnology has generated a need for design tools that can incorporate sufficiently detailed models of the nanoscale molecular phenomena with overarching transport and related effects in microfluidic devices. Currently, [...]

Scaling of Electroosmotic Flow and Ionic Conductivity in Nanochannels

Qiao R., Aluru N.R., Beckman Institute for Advanced Science and Technology, US

Electrokinetic transport is widely encountered in many nanofluidic systems, and understanding its scaling as a function of various operating conditions, e.g., bulk concentration, is important for establishing design rules and for exploring the design space. [...]

Multiscale Modeling of Nanoflows

Drazer G., Acrivos A., Khusid B., Koplik J., New Jersey Institute of Technology, US

Using molecular dynamics simulations, we identified in previous work a new adsorption phenomenon in which, for poorly wetting fluids, a suspended particle, initially moving along the center of the nanochannel, is adsorbed onto the tube [...]

Computational Analysis of On-line Coupled ITP-CE

Horner M., Fluent, Inc., US

Lab-on-a-chip technologies combine a sequence of chemical and/or biological analyses on a miniaturized platform to perform an analytical task or series of tasks. Lab-on-a-chip applications include chemical/biological agent detection, DNA sequencing/analysis, and drug discovery, to [...]

System Simulations of Complex Electrokinetic Passive Micromixers

Wang Y., Lin Q., Mukherjee T., Carnegie Mellon University, US

This paper presents a composable system simulation framework using an analog hardware description language implementing behavioral models for electrokinetic micromixers that are capable of accurately capturing the effects of mixer topology/geometry, flow ratio and material [...]