Materials for Drug & Gene Delivery – Page 27

Nanoconjugates of poly(malic acid) with functional modules for drug delivery

Ljubimova J.Y., Fujita M., Lee B-S, Khazenzon N.M., Wachsmann-Hogiu S., Farkas D.L., Black K.L., Holler E., Cedars-Sinai Medical Center, US

Nanoconjugates of β-poly(L-malic acid) (PMLA) have been synthesized with modules active in drug delivery, drug release, blocking of tumor-affiliated mRNA by antisense oligonucleotides, penetration of blood and cellular barriers, tissue targeting, membrane permeation, fluorescence, and [...]

In Vivo Tracking of Liposomes Using CT and MR Imaging

Zheng J., Liu J., Jaffray D.A., Allen C., University of Toronto, CA

Currently, there are limited methods available for longitudinal and non-invasive in vivo assessment of the transport kinetics of carrier-based therapeutics, such as those relying on liposomes. A viable strategy to non-invasively track the carrier in [...]

Nanotechnology for Drug Delivery: An Overview

Amiji M.M., Northeastern University, US

Nanotechnology is expected to have a revolutionary impact on biology and medicine. In this paper, I will discuss the role of nanotechnology in development of site-specific drug delivery systems. Polymeric nanoparticles, lipid nanosystems, and self-assembling [...]

Drug Delivery

Controllable Preparation of 10 nm Solid Lipid Nanoparticles based on Phase Behaviors of Drug-Loading Hot Microemulsions

Xia Q., Lu Y., Gu N., Southeast University, CN

A new method was presented for controllable preparation of 10-nm-scale drug carriers based on the phase behaviors of hot microemulsions. This method is suitable for preparation of nanodrug of many water insoluble drugs.

Protein Nanoparticles

Castor T.P., Aphios Corporation, US

Protein nanoparticles can be utilized for the pulmonary delivery of protein therapeutics or can be incorporated into biodegradable polymer microspheres/nanospheres for controlled release depot or oral delivery. With proteinaceous therapeutics, the generation of nanoparticles is [...]

Enhanced Gene Delivery Efficiency in Resonant Acoustic Fields

Lee Y-H, Peng C-A, University of Southern California, US

Enhancement of DNA delivery efficiency has been improved by several physical and chemical approaches in the past decade. However, the application of those methods is hampered by large-scaled configurations. To augment gene delivery efficiency with [...]

Nano-structured Chitosan Self-Aggregates as a Drug Delivery Carrier

Bae M.S., Kwon I.C., Jeong S.Y., Lee K.Y., Hanyang University, KR

A number of novel delivery systems have been developed including the entrapment of drugs, proteins, antigens, or genes in small vesicles or within polymeric matrices. Colloidal delivery systems such as liposomes, microemulsions, and polymeric micelles [...]

Multi-scale Drug Release Modeling for Targeted Oral Drug Delivery (TODD)

Haddish B.N., Nyquist C., Haghighi K., Wu H.A., Corvalan C., Rickus J., Keshavarzian A., Purdue University, US

Conventional oral dosage forms deliver their active ingredient at rates that are high initially and decline afterward, showing a first order kinetics with the release determining step considered as the dissolution rate of the active [...]

New Highly Efficient Non-invasive Nanoparticulate Delivery Systems for the Treatment of Chronic Diseases

Sinner F.M., Institute of Medical Technologies and Health Management, Joanneum Research, AT

We herein report the overall goals of the joint project “Nano-Health” and preliminary results of two sub-projects (Nano-Health started in October 2004), which was positive evaluated by international reviewers within the first Call of the [...]