Materials for Drug & Gene Delivery – Page 28

Superparamagnetic Iron Oxide Nanoparticles for Multiple Biomedical Applications

Hofmann H., Hofmann M., Petri-Fink A., Steitz B., von Rechenberg B., Hofmann H., Hofmann M., Juillerat J., Swiss Federal Institute of Technology Lausanne, CH

Superparamagneticiron oxide nanoparticles (SPION) were mixed at various ratios with different polymer solutions to obtain SPION coated with PVA modified by functional groups (amino-SPION, carboxy-SPION, and thiol-SPION). Studying human melanoma cells by theses different functionalized [...]

pH-Responsive Hydrogel with Controlled Swelling and Degradation Rate

Trujillo-Lemon M., Bowman C.N., Stansbury J.W., University of Colorado Denver and Health Sciences Center, US

Degradable polymeric materials that can be storage for months in aqueous enviroment before undergoing on-command controlled swelling and degradation were prepared and their kinetics of swelling and degradation were evaluated. The swelling and degradation rates [...]

Carbon Coated Magnetic Nanoparticles for Local Drug Delivery using Magnetic Implants

Fernández-Pacheco R., Ibarra M.R., Valdivia J.G., Marquina C., Serrate D., Romero M.S., Gutiérrez M., Arbiol J., Institute of Nanoscience of Aragon, ES

Bioferrofluid obtained using iron coated nanoparticles are promising candidates for magnetic drug delivery. The carbon cages made the particles biocompatibles and provide a suport for drug adsortion. We propose a new method in which gold [...]

Nano-Structured Vaccine Delivery

Yang Y-W, Wu C-A, National Taiwan University, TW

The nano-structured vaccine delivery systems, containing tomatine, n-octyl-b-D-glucopyranoside (OGP), phosphatidylethanolamine (PE), cholesterol, and ovalbumin, were examined in the present study by transmission electron microscopy. This adjuvant has been shown to elicit cytoxic T-lymphocyte (CTL) effect [...]

Polymeric Hybrid Microstructures for Smart Targeting and Drug Delivery

Dudia A., Kanger J.S., Subramaniam V., University of TWente, NL

Artificial cells (AC) refer to (sub) micro-vehicles that can perform a specific bio-function in the body, without being rejected from the immune system. Such smart targeting and drug delivery systems are aimed for use in [...]

Feasibility of Superparamagnetic Nanoparticles for Drug Delivery to the Inner Ear

Dormer K., Mamedova N., Kopke R., Liu J., Chen K., Gibson D., Jackson R., Costello M., Mondalek F., NanoBioMagnetics, Inc, US

An obstacle to effective treatment of inner ear diseases is the atraumatic delivery of therapeutics into inner ear perilymph. This study reports on the feasibility of using superparamagnetic nanoparticles as drug delivery vehicles.

Structural Characterization of Novel Micro- And Nano-Scale Non-Viral DNA Delivery Systems for Cutaneous Gene Therapy

Foldvari M., Badea I., Wettig S., Verrall R., Bagonluri M., University of Saskatchewan, CA

Our main goal is to develop micro/nano-scale self-assembling delivery vehicles for cutaneous gene therapy. The objective of this study was to characterize the structural and physicochemical properties of novel dicationic lipid-based DNA complexes by atomic [...]

Nanoparticulate Drug Delivery Systems Based on Hydrotropic Polymers, Dendrimers, and Polymer Complexes

Park J.H., Park K., Huh K.M., Lee S-C, Lee W-K, Lee S-C, Lee W-K, Ooya T., Park J.H., Park K., Purdue University, US

Novel nanoparticulate drug delivery systems have received increasing attention for delivery of poorly water-soluble drugs and proteins. We have developed a new type of polymer micelles bearing the hydrotropic core segment, e.g., poly(2-(4-vinylbenzyloxy)-N,N-diethylnicotinamide), that enables [...]

Two-Dimensional Chemotherapy Simulations Demonstrate Fundamental Transport and Tumor Response Limitations Involving Nanoparticles

Sinek J., Frieboes H., Zheng X., Cristini V., University of California Irvine, US

Zheng et al. (2004) developed a multiscale, twodimensional tumor simulator with the capability of showing tumoral lesion progression through the stages of diffusion-limited dormancy, neo-vascularization (angiogenesis) and consequent rapid growth and tissue invasion. In this [...]

Formation of Nanoparticles of a Hydrophilic Drug using Supercritical CO2 and Microencapsulation for Sustained Drug Release

Thote A.J., Gupta R.B., Auburn University, US

The problem of initial burst release, in sustained drug delivery devices was resolved by reducing the active pharmaceutical ingredient particle size by using Supercritical Antisolvent technique with Enhanced Mass-transfer (SAS-EM)., Encapsulation was performed using a [...]