Materials for Drug & Gene Delivery – Page 26

Functional Stimuli-Responsive Nanogel-particles for Oral Peptide Delivery: Preparation, Drug-Release Behaviors and in Vitro Cellular Interaction

Ichikawa H., Fukumori Y., Kamiya H., Kobe Gakuin University, JP

The present study involves preparation and evaluation of novel core-shell nanoparticles (CSNPs) consisting of thermo-responsive poly(N-isopropylacrylamide) (p(NIPAAm)) hydrogel core with pH-responsive poly(methacrylic acid-grafted-poly(ethylene glycol)) (p(MAA-g-EG)) shell layer as a carrier for oral peptide delivery. The [...]

Chitosan Nanoparticles for the Effective Vaccine Delivery System

Kim B.G., Kang I.J., Kyungwon University, KR

There are four genes of S, C, X, P in HV DNA. S gene has the pre-S region composed of pre-S1 and pre-S2 as an encoding gene of surface antigen. C gene is in the [...]

Synthesis and Photodynamic Efficacy of PAMAM-Photosensitiser Conjugates in Vitro

Peng C.L., Lai P.S., Lai T.-Y., Chiu C.H., Chang C-C, Lai P.S., Lai T.-Y., Shieh M.J., National Taiwan University, TW

Starburst polyamidoamine (PAMAM) dendrimer is a new class of highly branched spherical polymer. Covalent attachment of porphyrin to PAMAM dendrimer may alter the pharmacokinetics, cell targeting, and photophysical properties of photosensitizer. We investigated the uptake, [...]

Synergistic Release of DNA from pH Responsive Polyion Complexes (PICs)

Harper G., WetaScience, UK

Polyelectrolyte complexes based on an outer layer of cationic polyhydroxylamine (PT) were prepared on carboxylated microparticles pretreated with polyamine (A) and a middle layer of Polyacrylic Acid (PA). A synergistic effect between PT and PA [...]

A Novel Biodegradable System Based on BSA/PCL Core-shell Structured Nanofibers for Controlled Drug Delivery

Feng Y., Zhang Y.Z., Yong T., Ramakrishna S., National University of Singapore, SG

Electrospun core-shell structured nanofibers encapsulating BSA were explored as a potential drug delivery model in a biological system in present study. These nanofibers were prepared by coaxial electrospinning method with poly (caprolactone) (PCL) as the [...]

Microscopic Mechanism of Sonoporation

Prentice P.A., Burns J.M., Cuschieri A., Campbell P.A., University of Dundee, UK

This paper will expand on our recent paper in Nature Physics (November 2005) and will show that the initial observations can be extended from rigid albumin systems to flexible lipid based microbubbles also. We will [...]

Cationic Nanoparticles based on pH Responsive Polyion Complexes containing Plasmid GFP DNA

Harper G., Gibbs R., WetaScience, UK

Cationic nanoparticles were formulated from a polycationic Polyhydroxylamine (PT) with low pKa and polyanionic PolyAcrylic Acid (PA) that form binary polyelectrolyte complexes (PECs). Particles spontaneously form on component mixing with sizes between 80-700nm and particle [...]

Formulation Optimization for the Nanoparticles-in-Microsphere Hybrid Oral Delivery Systems Using Factorial Design

Bhavsar M.D., Tiwari S.B., Amiji M.M., Northeastern University, US

The objective of the present study was to optimize the processing parameters for nanoparticles-in-microsphere hybrid system for oral delivery (NiMOS) and to mathematically relate the process parameters with the selected attribute (particle size) of the [...]

Shell Cross-Linked Nanoparticle Based on Poly(e-caprolactone)-Poly(ethylene glycol) for Photosensitizer Delivery

Lai P.S., Huang M.Y., Wang S.J.J., Chen C.N., Shieh M.J., National Taiwan University, TW

Photodynamic therapy (PDT) is a novel photochemical process for producing localized tissue necrosis, which involves the activation of a photosensitizing drug in the target tissue with light of a specific wavelength matched to an absorption [...]

Development of a Novel Triblock Copolymer Therapeutic Nanoreactor

Ranquin A., De Vocht C., Meier W., Steyaert J., Van Gelder P., VUB, BE

Currently chemotherapy is one of the major strategies to treat cancer patients. It is however limited by several drawbacks such as low bioavailability of chemotoxins, low drug concentrations at the tumor site, systemic toxicity, lack [...]