Environmental Health & Safety of Nanomaterials – Page 9

Quantitative Assessment of Nanoparticle Induced Oxidative DNA Damage Using Isotope Dilution Mass Spectrometry

Petersen E.J., Marquis B.J., Jaruga P., Dizdaroglu M., Nelson B.C., National Institute of Standards and Technology, US

Hyphenated mass spectrometry (gas chromatography/mass spectrometry) techniques have been employed as one of the primary analytical tools for investigating the effects of ionizing radiation, chemical/biological carcinogens and oxygen derived free radicals on the induction and [...]

“Just Add Water” – “Instant” singly-dispersed suspensions of silver nanoparticles on demand

MacCuspie R.I., National Institute of Standards and Technology, US

The rapid pace of development of new nanomaterials and new applications has also attracted much attention from the environmental health and safety (EHS) risk assessment community. Subsequently, calls for well-characterized common test materials from a [...]

Bio-compatibility of silver nanomaterials using the embryonic zebrafish bioassay

Fisher J.A., Tanguay R.L., Oregon State University, US

The bio-compatibility of silver nanomaterials (AgNP) is currently of great interest to regulators and health and safety professionals because it is a material that has the potential to reach mass populations. Four well characterized (Harper [...]

Entry of Short Multi-Wall Carbon Nanotubes into Dorsal Root Ganglion (DRG) Neurons Induces Cell Death

Lai J.C.K., Gao W., Bhushan A., Bearden S.E., McDougall L., Leung S.W., Idaho State University College of Pharmacy, US

Carbon nanotubes (CNTs) have found their way into diverse industrial and biomedical applications because of their unique physico-chemical properties. However, the human health impact of exposure to CNTs is unknown. Our recent and ongoing studies [...]

ROS Evaluation for Series of CNTs Using the ESR Method and the Effects of CNT Mophology

Tsuruoka S., Takeuchi K., Koyama K., Endo M., Fujisawa K., Matsumoto H., Saito N., Usui Y., Porter D.W., Castranova V., Shinshu University, JP

Carbon nanotubes (CNTs) are becoming important materials in industry. It is a concern that CNTs may induce carcinogenic responses through pulmonary exposure. It has been recently reported1-6 that CNTs scavenge ROS depending on their morphology. [...]

Oxidatively Induced Damage to DNA: Potential Roles of Single- and Multi-Wall Carbon Nanotubes at the Molecular Level

Nelson B.C., National Institute of Standards and Technology, US

Carbon nanotubes (CNTs) are remarkable materials in terms of their enhanced thermal and electrical conductivities, tensile strengths and mechanical properties. Because of these unique properties, the commercial development and application of CNTs in electronics, advanced [...]

Toxic Potential of Food-Relevant Nanoparticles in the Intestinal Epithelium

McCracken C., Zane A., Knight D., Dutta P., Waldman W.J., The Ohio State University, US

Oral exposure to nanoparticles incorporated in foods is increasingly common. However, the effects of these nanoparticles when ingested are still unknown. Thus, this investigation tested the hypothesis that nanoparticle toxicity is dependent on particle size, [...]

Cytotoxicity and biointeractions of nanosilver in macrophages

Pratsinis A., Pratsinis S.E., Hervella P., Leroux J.-C., Pratsinis A., Pratsinis S.E., Sotiriou G.A., ETH Zürich, CH

Silver nanoparticles (nanosilver) are broadly used today in textiles, food packaging, household devices and bioapplications, prompting a better understanding of their toxicity and biological interactions. Here, nanosilver of well-defined size (5.7 to 20.4 nm) supported [...]

Zinc Oxide Nanoparticles Induced Apoptosis and Necrosis in Hepatocellular Carcinoma HepG2 Cells

Tadinada S.M., Lai J.C.K., Lai M.B., Idikuda V.K., Mukka K., Singh M.R.M., Pfau J., Bhushan A., Leung S.W., Lai J.C.K., Lai M.B., Idaho State University College of Pharmacy, US

Targeted drug delivery systems with minimal potential adverse/side effects are gaining utility in diverse applications. Uses of nanomaterials to design such targeted drug delivery are escalating exponentially. Nevertheless, the biocompatibility of nanomaterials is inadequately addressed. [...]

Titanium Dioxide Nanoparticles Interaction, Uptake and Genotoxicty in Salmonella typhimurium Bacteria

Casey B.J., Butler K.S., Elespuru R.K., Dair B.J., U.S. Food and Drug Administration, US

Due to their unique properties the use of nanoparticles (NPs) in consumer products is increasing rapidly. The expanding prevalence of NPs make it critical to understand the associated risk to both the public health along [...]