Nelson B.C. – TechConnect Briefs

Quantitative Analysis of Oxidation State in Cerium Oxide Nanomaterials

Sims C.M., Maier R.A., Johnston-Peck A.C., Gorham J.M., Hackley V.A., Nelson B.C., National Institute of Standards and Technology, US

Of the many engineered nanomaterials being incorporated into our society, cerium oxide (ceria, CeO2-x) based nanomaterials (NMs) are receiving increased attention due to their unique chemical properties and vast number of current and potential applications [...]

Single Wall Carbon Nanotube Inhibition of DNA Damage

Nelson B.C., NIST, US

Carbon nanotubes (CNTs) are remarkable materials in terms of their enhanced thermal and electrical conductivities, tensile strengths and mechanical properties. However, our understanding of the potential environmental, health and safety risks of these novel nanomaterials [...]

Using single particle ICP-MS as a tool for understanding metallonanoparticles transformation during nanotoxicity assays

Johnson M.E., Hanna S.K., Petersen E.J., Nelson B.C., Yu L.L., National Institute of Standards and Technology, US

The work presented will establish a method for employing SP-ICP-MS toward the characterization of ENPs following their exposure to a model organism, C. elegans. Sample preparation, SP-ICP-MS analysis, data processing, particulate transport efficiency evaluation, and [...]

Quantitative Assessment of Nanoparticle Induced Oxidative DNA Damage Using Isotope Dilution Mass Spectrometry

Petersen E.J., Marquis B.J., Jaruga P., Dizdaroglu M., Nelson B.C., National Institute of Standards and Technology, US

Hyphenated mass spectrometry (gas chromatography/mass spectrometry) techniques have been employed as one of the primary analytical tools for investigating the effects of ionizing radiation, chemical/biological carcinogens and oxygen derived free radicals on the induction and [...]

Oxidatively Induced Damage to DNA: Potential Roles of Single- and Multi-Wall Carbon Nanotubes at the Molecular Level

Nelson B.C., National Institute of Standards and Technology, US

Carbon nanotubes (CNTs) are remarkable materials in terms of their enhanced thermal and electrical conductivities, tensile strengths and mechanical properties. Because of these unique properties, the commercial development and application of CNTs in electronics, advanced [...]

Tools and Approaches for the Assessment of Nanomaterial Induced Oxidative DNA Damage

Petersen E.J., Marquis B.J., Jaruga P., Dizdaroglu M., Nelson B.C., National Institute of Standards and Technology, US

Determining the effects of various surface coatings on carbon nanotubes (CNTs) is critical given the numerous expected applications of CNTs and their inevitable release into ecosystems. To explore the potential ecotoxicological effects of CNT surface [...]