Diagnostics & Bioimaging – Page 8

Mechanism and Free Energy of DNA Hybridization on Single-Walled Carbon Nanotubes Using Adaptive Biasing Force Simulations

Chien M.W., Johnson Jr. A.T.C., Johnson R.R., Pillai S., Singh S.R., Johnson Jr. A.T.C., Johnson R.R., University of Pennsylvania, US

DNA-carbon nanotube hybrids (DNA-NT) consist of single stranded DNA self-assembled to the sidewall of single-walled carbon nanotubes. DNA-NT show great promise for applications in nanotechnology, including chemical sensing and sequence-specific DNA detection. Details of the [...]

Study the Correlations Between Direct Electron Transfer Rate Constants in Four Types of Nanobiomimetic Sensors and the Ability to Kill Cancer Cells from Anti-Cancer Candidate Compounds

Chen E.T., Thornton J., Ngatchou C., Duh S-H, Kissinger P.T., Advanced Biomimetic Sensors, Inc., US

We report a new approach to study Direct Electron Transfer (DET) rate constants between an electrode surface and an active biomimetic receptor using four types of gold nanobiomimetic sensors. The goal is to find the [...]

Rapid Evaluation of Bacterial Antibiotic Resistance

Longo G., Alonso-Sarduy L., Pekkanen J., Dietler G., Kasas S., Ecole Polytechnique Federale Lausanne, CH

Antibiotics represent one of mankind’s most important medical inventions, yet antibiotic resistance has emerged as a significant health-care problem due to the extensive use and misuse of antibiotics in human and veterinary medicine. Suppressing the [...]

Challenges in the Characterisation of Therapeutic Protein Formulations

Ball S., Pothecary M., Clarke P., Murphy C., Malvern Instruments, UK

In recent years, the stability of proteins in solution has attracted significant scientific and commercial interest due to the exponential growth in the use of proteins as biotherapeutic drugs. Since knowledge of formulation stability and [...]

Probing the Distribution of Gliadin in Dough and Baked Bread Using Conjugated Quantum Dots as a Labeling Tool

Ansari S., Kokini J., University of Illinois at Urbana-Champaign, US

Nowadays quantum dots (QDs) technology is most commonly used in medical application as a probe to diagnostic procedures and also for designing of biosensors. However, the application of this technology is very new in food [...]

Raman Imaging for Characterization of Novel Multi-Layer Solid Dosage Forms

Rzhevskii A., Thermo Fisher Scientific, US

Multi-layer tablets, combination drug formulations and other innovative dosage forms are getting increasing attention in pharmaceutical industry. As structure and composition of the multi-layer dosages become more complicated, the development and application of techniques for [...]

Multilayer Architectures of Enzymes on Electrodes for Sensorial Application – Influence of the Building Blocks on the Assembly Behaviour

Lisdat F., Technical University Wildau, DE

The presentation will illustrate how redox proteins can be arranged in multiple layers on electrodes while retaining full electroactivity without the use of mediators. Enzymes can be integrated into such systems to result in sensing [...]

Influence of metallic, ceramic, and plastic MALDI surface materials on the ionization efficiency and quality of mass spectrometric data

Hieke A., Stanford University, School of Medicine, US

Imperfections of the MALDI ionization process of proteins and peptides impose considerable limitations on the utility of mass spectrometry in basic life sciences and ultimately on the application in biomarker discovery and medical diagnostics. Improved [...]

Triplet-Triplet Annihilation Upconversion in Water Environment: Biocompatible and Non-invasive All-optical Temperature Sensing for Living Objects

Busko D., Dimitrova R., Turshatov A., Avlasevich Y., Landfester K., Baluschev S., Max Planck Institute for Polymer Research, DE

A realistic temperature sensing alternative for life-science objects could be the process of triplet-triplet annihilation upconversion in water environment (TTA – UC): It is inherently micro-scale sensing techniques – the sensing function is carried out [...]

Continuous Flow Real-Time Pcr Platform for High Throughput Environmental Monitoring

Ray T., Hatch A., Lintecum K., Chao S-H, Youngbull C., Arizona State University, US

We present the design and development of a continuous flow quantitative Polymerase Chain Reaction system, suitable for multi-analyte, high-throughput, semi-autonomous assays. This system operates in a continuous fashion and is able to detect many different [...]