Biomaterials – Page 96 – TechConnect Briefs

On Chip Induced Phagocytosis for Improved Neuronal Cell Adhesion

Van Meerbergen B., Raemaekers T., Winters K., Braeken D., Bartic C., Engelborghs Y., Annaert W., Borghs G., IMEC, BE

Efficient integration of neuronal cells and electronic devices could result in hybrid bi-directional communication systems that would enable us to interact at fundamental level with biological structures and get insight in the mechanisms governing their [...]

Enzymatically Degradable Hydrogel Nanocomposite for Bone Regeneration

Jabbari E., He X., Sarvestani A.S., University of South Carolina, US

One approach to bone replacement involves the use of in-situ crosslinkable scaffolds for cell transplantation to promote tissue growth, nutrient diffusion, matrix production, and vascularization. Bone matrix is a composite material consisting of aqueous and [...]

Nano-Hydroxyapatite Coated Acetabular Cup Implant by Electrophoretic Deposition

Zhang H., Zhang Z., Krajewski J., Zhang H., Zhang Z., Xiao T.D., Reisner D., Inframat Corporation, US

A nanostructural hydroxyapatite (HA) coating was deposited to the porous Ti6Al4V hip cup implant using electrophoretic deposition (EPD) in order to improve the bonding strength between the implants and cells, fast healing, good resistance to [...]

Nanoscale Analysis of Bone Mineral Crystals

Chen H., Robinson C., Shore R.C., Brookes S.J., Zhang J., Smith D.A., Clarkson B.H., Kirkham J., University of Michigan, US

The mineral component of both bones and teeth comprises of crystals of calcium hydroxyapatite. However, there are very few studies which have characterised and compared individual crystals from these mineralised tissues at the nanoscale. In [...]

Wettability Engineering and Bioactivation of Hydroxyapatite Nanoceramics

Rosenman G., Aronov D., Tel Aviv University, IL

The major trends in biotechnology and tissue engineering are development of materials with controlled surface substrates. One of the critical factors influencing adhesion of biocells is wettability properties of the biomimetic substrates. Hydrophilicity (hydrophobicity) of [...]

Less Harmful Acidic Degradation of Poly(lactide-co-glycolide) Bone Tissue Engineering Scaffolds through Titania Nanoparticle Addition

Liu H., Slamovich E.B., Webster T.J., Purdue University, US

In the last ten years, biodegradable aliphatic polyesters, such as poly(lactide-co-glycolide) acid (PLGA), have attracted increasing attention for their use as scaffold materials in bone tissue engineering because their degradation products can be removed by [...]

In vitro human model for tumor target screening in Cancer research

Mertsching H., Weimer M., Brunner H., Fraunhofer Institute of Interfacial Engineering and Biotechnology, DE

Monolayer and suspension cultures are still a highly artificial cellular environment for target screening and drug development. They have limited predictive value for target screening especially for nanomaterials. Target screening requires testsystems that mimic the [...]

Polysaccharide based Nanoparticles and Nanoporous matrices

Fojan P., Schwach-Abdellaoui K., Tommeraas K., Gurevich L., Petersen S.B., Aalborg University, DK

We have successfully obtained good quality SPM images of the gel state of selected polysaccharides. The images reveal a surprisingly flat surface richly decorated with 30-50 nm deep pores. This type of insight we believe [...]

Bio Materials and Tissues

Functionalization of Magnetite (Fe3O4) Nanoparticles for Cancer Treatment

Herrera A.P., Rodríguez H.L., Torres-Lugo M., Rinaldi C., University of Puerto Rico-Mayagüez, US

We have studied the synthesis of magnetite (Fe3O4) nanoparticles functionalized with crosslinked dextran for magnetocytolysis application using human colon cancer cells (CaCo-2). Size of the magnetite nanoparticles was determined by SQUID, XRD, and TEM measurements, [...]