We have successfully obtained good quality SPM images of the gel state of selected polysaccharides. The images reveal a surprisingly flat surface richly decorated with 30-50 nm deep pores. This type of insight we believe [...]
Monolayer and suspension cultures are still a highly artificial cellular environment for target screening and drug development. They have limited predictive value for target screening especially for nanomaterials. Target screening requires testsystems that mimic the [...]
In the last ten years, biodegradable aliphatic polyesters, such as poly(lactide-co-glycolide) acid (PLGA), have attracted increasing attention for their use as scaffold materials in bone tissue engineering because their degradation products can be removed by [...]
The major trends in biotechnology and tissue engineering are development of materials with controlled surface substrates. One of the critical factors influencing adhesion of biocells is wettability properties of the biomimetic substrates. Hydrophilicity (hydrophobicity) of [...]
The mineral component of both bones and teeth comprises of crystals of calcium hydroxyapatite. However, there are very few studies which have characterised and compared individual crystals from these mineralised tissues at the nanoscale. In [...]
A nanostructural hydroxyapatite (HA) coating was deposited to the porous Ti6Al4V hip cup implant using electrophoretic deposition (EPD) in order to improve the bonding strength between the implants and cells, fast healing, good resistance to [...]
One approach to bone replacement involves the use of in-situ crosslinkable scaffolds for cell transplantation to promote tissue growth, nutrient diffusion, matrix production, and vascularization. Bone matrix is a composite material consisting of aqueous and [...]
Efficient integration of neuronal cells and electronic devices could result in hybrid bi-directional communication systems that would enable us to interact at fundamental level with biological structures and get insight in the mechanisms governing their [...]
, Carbone R.
, Clerici E.
, Giorgetti L.
, Lanfrancone L.
, Marangi I.
, Milani P.
, Minucci S.
, Pelicci P.G.
, Piseri P.
, Zanardi A.
, European Institute of Oncology, IT
Primary human melanocytes represent the precursor cells to melanoma and also specific targets of inherited and acquired pigmentation disorders (1,3). The possibility to genetically manipulate these cells for biological studies or therapy has not been [...]
The organization of cells within an extracellular matrix is critical to promote appropriate cellular interactions and tissue function in vivo. The ability to design and create a nano-patterning on surfaces provides new capabilities for tissue [...]
Titanium and cobalt-based alloys are two main groups of metallic materials widely used in orthopedic applications. One approach to improve biological properties of current titanium and CoCrMo implant is to mimic the nanostructures of natural [...]
New implants are studied in vivo under the conditions, when the replaced defect is located on the bone, which accomplishes motions with the large amplitude and with the large load.Three types of implants were placed [...]
The research is based on the differentiation of stem cells on carbonnanofibers.
The control of interactions between living cells and modified surfaces is important for tissue engineering and may assist in the fabrication of bioactive coatings. Here we investigated the attachment of fibroblasts cells on bio-surfaces fabricated [...]
There are a number of applications requiring bone-building agents. For example, osteoporosis is a disease resulting in weak bone. However, no current effective prevention and treatment methods exist for osteoporosis. For these reasons, in this [...]
Surfactants are known to influence functions of many proteins in membranes, cells and tissues. Because most studies to elucidate the effects of surfactants on membrane-bound proteins and cells employed heterogeneous or complex systems, it is [...]
We present here an innovative three dimensional microfabrication technology that will serve as a vehicle to enable vascularized bioreactors for in vitro tissue culture. The core of our microfabrication technology is a high-resolution projection micro [...]
One potential advantage of nanotechnology is the ability to engineer bottom-up hierarchical assembly of nanoparticles into functional macroscale materials and devices. The most promising mechanism for accomplishing this is self-assembly. In this project, an advanced [...]
The nanofiber technology of present interest focuses on the electrospinning technique, which conveniently allows the preparation of fibrous materials with very fine diameters ranging from submicron to several nanometers. With the ability to form nanofibrous [...]
We established a tissue engineered 3D human skin model. This interactive 3D-co-cultre consists of living human primary keratinocytes with a well-differentiated stratum corneum and an epidermal layer. The dermal layer is composed of a Type [...]
The typical end-product of the electrospinning process is a randomly aligned fibre mesh or membrane. This is a result of the electric field generated between the drop of polymer solution at the needle and the [...]
Self-assembling DNA nanostructures are currently being developed for a variety of applications in nanofabrication and molecular computing. For many uses, these nanostructures would benefit from increased thermal stability. However, increasing the lengths of sticky-ends that [...]
Journal: TechConnect Briefs
Volume: 2, Technical Proceedings of the 2006 NSTI Nanotechnology Conference and Trade Show, Volume 2
Published: May 7, 2006
Industry sector: Medical & Biotech