Biomaterials – Page 78 – TechConnect Briefs

Sirna Nanomedicines for Cancer Gene Therapy

Kim S-H, Park T.G., Korea Advanced Institute of Science and Technology, KR

We developed a polyelectrolyte complex (PEC) micelle-based delivery system for treatment of prostate cancer. A PEGylated siRNA targeting human vascular endothelial growth factor (hVEGF) was synthesized. The hVEGF expression was almost completely inhibited in vitro [...]

Development of a specific micro/nanodevice validating the concept of molecular biopsy

Berger F., Bouamrani A., Cosnier M., Martin F., Caillat P., Benabid A.L., Inserm, FR

The nanomedicine concept implies early detection at the molecular level and molecular characterisation to implement a specific therapy. In this context, the development of micro/nanotool devoted for intra-tissular characterisation is indispensable. We first demonstrated that [...]

Characterization and in vivo efficacy of targeted nanoparticles for systemic siRNA delivery to tumors

Bartlett D.W., Davis M.E., California Institute of Technology, US

This abstract highlights the results from our latest work in the design and application of targeted nanoparticles for systemic siRNA delivery. Over the past several years, we have performed extensive physicochemical and biological characterization of [...]

Development of Nanoconjugate with Different Monoclonal Antibodies to Inhibit Molecular Targets Important for Tumor Angiogenesis

Fujita M., Khazenzon N.M., Lee B-S, Holler E., Black K.L., Ljubimova J.Y., Cedars-Sinai Medical Center, US

Tumor cell-specific drug targeting is the major goal of nanotechnology-based platforms. A nanoconjugate Polycefin was synthesized for targeted delivery of antisense oligonucleotides and antibodies into tumors. The delivery of antisense oligonucleotides to α4 and β1 [...]

Cancer Diagnostics, Imaging & Treatment

Electrospun Microfiber Tubes and Self-Assembling Peptides Stimulate Neural Regeneration in Rat Sciatic Nerve Transections

Gelain F., Panseri S., Modica L., Taraballi F., Lowery J., Vescovi A., University of Milan-Bicocca, IT

Peripheral nerve injury is still a traumatic pathology that may impair patient’s movements by interrupting his motor-sensory pathways. New synthetic nerve grafts comprising electrospun tubes and tailored self-assembling peptides are used in our study to [...]

Using Chondroitin Sulfate to Synthesize Nanoparticles

Vercruysse K.P., Williams A., Ivory D., Johnson B., Dixon R.D., Tran M.T., Moore J.T., Tennessee State University, US

We provide evidence that chondroitin sulfate (CS), a member of the glycosaminoglycan (GAG) family of polysaccharides found in the extracellular matrix of all higher order species, can be used as a matrix to generate nanosized [...]

In vitro & in vivo toxicity of CoFe2O4 nanoparticles for application to magnetic hyperthermia

Kim D-H., Kim K-M, Kim K.N., Kim D-H., Kim K-M, Kim K.N., Kim D-H., Kim K-M, Kim K.N., Shim I-B, Lee Y.K., The University of Alabama, Tuscaloosa, US

Magnetic nanoparticles offer some attractive possibilities in biomedicine because it has the special physical properties. So, we can usually consider four particular applications: magnetic separation, drug delivery, hyperthermia treatments and magnetic resonance imaging (MRI) contrast [...]

Nano-Surface Behavior of Osteoblast Cell-Cultured Ti-30(Nb,Ta) with Low Elastic Modulus

Choe H.C., Ko Y.M., Brantley W., Chosun University, KR

Ti and Ti-alloys have good biocompatibility, appropriate mechanical properties and excellent corrosion resistance. However, the widely used Ti-6Al-4V is found to release toxic ions (Al and V) into the body, leading to undesirable long-term effects. [...]

Silicon Dioxide Nanoparticles Can Exert Cytotoxic Effects on Neural Cells

Lai J.C.K., Lai M.B., Lai J.C.K., Lai M.B., Edgley K.L., Bhushan A., Dukhande V., Daniels C.K., Leung S.W., Idaho State University, US

The health risk and cytotoxic effects of nanoparticles are almost unknown. Consequently, we have launched an interdisciplinary research program to systematically investigate the toxicity of nanoparticles. An initial observation prompted us to hypothesize that SiO2 [...]